2023 article
Age-associated changes in electroretinography measures in companion dogs
Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA.
author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
TL;DR:
Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 19, 2023
{"Label"=>"PURPOSE", "NlmCategory"=>"OBJECTIVE"} To determine the association between age and retinal full-field electroretinographic (ERG) measures in companion (pet) dogs, an important translational model species for human neurologic aging. {"Label"=>"METHODS", "NlmCategory"=>"METHODS"} Healthy adult dogs with no significant ophthalmic abnormalities were included. Unilateral full-field light- and dark-adapted electroretinography was performed using a handheld device, with mydriasis and topical anaesthesia. Partial least squares effect screening analysis was performed to determine the effect of age, sex, body weight and use of anxiolytic medication on log-transformed ERG peak times and amplitudes; age and anxiolytic usage had significant effects on multiple ERG outcomes. Mixed model analysis was performed on data from dogs not receiving anxiolytic medications. {"Label"=>"RESULTS", "NlmCategory"=>"RESULTS"} In dogs not receiving anxiolytics, median age was 118 months (interquartile range 72-140 months, n = 77, 44 purebred, 33 mixed breed dogs). Age was significantly associated with prolonged peak times of a-waves (dark-adapted 3 and 10 cds/m {"sup"=>"2"} flash p < 0.0001) and b-waves (cone flicker p = 0.03, dark-adapted 0.01 cds/m {"sup"=>"2"} flash p = 0.001). Age was also significantly associated with reduced amplitudes of a-waves (dark-adapted 3 cds/m {"sup"=>"2"} flash p < 0.0001, 10 cds/m {"sup"=>"2"} flash p = 0.005) and b-waves (light-adapted 3 cds/m {"sup"=>"2"} flash p < 0.0001, dark-adapted 0.01 cds/m {"sup"=>"2"} flash p = 0.0004, 3 cds/m {"sup"=>"2"} flash p < 0.0001, 10 cds/m {"sup"=>"2"} flash p = 0.007) and flicker (light-adapted 30 Hz 3 cds/m {"sup"=>"2"} p = 0.0004). Within the Golden Retriever breed, these trends were matched in a cross-sectional analysis of 6 individuals that received no anxiolytic medication. {"Label"=>"CONCLUSIONS", "NlmCategory"=>"CONCLUSIONS"} Aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs.