2023 journal article
A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy
SCIENTIFIC REPORTS, 13(1).
MeSH headings : Humans; Proton Therapy / methods; Diagnostic Imaging; Protons; Gamma Rays; Radiotherapy Dosage; Monte Carlo Method; Phantoms, Imaging
TL;DR:
This study lays the foundation for multi-particle detection and imaging systems in the context of range verification in PT by proposing a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions.
(via Semantic Scholar)
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 19, 2023
AbstractParticle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models and detector resolution effects. The results indicate that range shifts of $${1}\,\hbox {mm}$$ 1 mm can be detected at relatively low proton intensities ($$22.30(13)\times 10^{7}$$ 22.30 ( 13 ) × 10 7 protons/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multi-particle detection and imaging systems in the context of range verification in PT.