2023 journal article

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<i>AHRR</i> Hypomethylation mediates the association between maternal smoking and metabolic profiles in children

HEPATOLOGY COMMUNICATIONS, 7(10).

By: A. Vidal ⁿ, S. Chandramouli^*, J. Marchesoni ⁿ , N. Brown  ⁿ, Y. Liu ⁿ, S. Murphy ^*, R. Maguire ⁿ, Y. Wang ⁿ ...and 7 other authors, including 3 NC State authors, M. Abdelmalek^*, A. Mavis ^*, M. Bashir ^*, D. Jima ⁿ, D. Skaar ⁿ, C. Hoyo ⁿ, C. Moylan ^*

TL;DR: AHRR hypomethylation significantly mediates the association between prenatal tobacco smoke exposure and features of childhood metabolic dysfunction, despite the lack of persistent hypometHylation of AHRR into childhood. (via Semantic Scholar)

10.1097/HC9.0000000000000243

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doi.org (publisher)

UN Sustainable Development Goal Categories

3. Good Health and Well-being (Web of Science; OpenAlex)

Source: Web Of Science

Added: October 16, 2023

Background: Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor (AHRR) gene is associated with in utero tobacco smoke exposure. In this study, we evaluated whether AHRR hypomethylation mediates the association between maternal smoking and metabolic dysfunction in children.