2024 journal article

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Investigation of integrated time nanosecond pulse irreversible electroporation against spontaneous equine melanoma

FRONTIERS IN VETERINARY SCIENCE, 11.

By: C. Fesmire ⁿ, B. Peal^*, J. Ruff^*, E. Moyer^*, T. McParland^*, K. Derks^*, E. O'Neil^*, C. Emke^* ...and 7 other authors, including 4 NC State authors, B. Johnson^*, S. Ghosh ⁿ, R. Petrella ⁿ, M. DeWitt ⁿ, T. Prange^*, C. Fogle^* , M. Sano ⁿ

author keywords: focal ablation; pulsed field ablation; INSPIRE; skin cancer; clinical trial

TL;DR: This novel therapeutic approach has the potential to expand the role of pulsed electric fields in veterinary patients, especially when general anesthesia is contraindicated, and warrants future studies to demonstrate the efficacy of INSPIRE as a solid tumor treatment. (via Semantic Scholar)

10.3389/fvets.2024.1232650

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www.frontiersin.org (publisher PDF)

UN Sustainable Development Goal Categories

3. Good Health and Well-being (OpenAlex)

Source: Web Of Science

Added: February 19, 2024

IntroductionIntegrated time nanosecond pulse irreversible electroporation (INSPIRE) is a novel tumor ablation modality that employs high voltage, alternating polarity waveforms to induce cell death in a well-defined volume while sparing the underlying tissue. This study aimed to demonstrate the in vivo efficacy of INSPIRE against spontaneous melanoma in standing, awake horses.