Utilizing multiscale engineered biomaterials to examine TGF-β-mediated myofibroblastic differentiation
Simpson, A., Krissanaprasit, A., Chester, D., Koehler, C., Labean, T. H., & Brown, A. C. (2024, March 9). WOUND REPAIR AND REGENERATION.
author keywords: biomaterials; DNA origami; fibrosis; mechanotransduction; microgel; TGF-beta
TL;DR:
It is found that highly viscous materials with non-fixed TGF-β-R spacing promoted increased TGF-β signalling and myofibroblastic differentiation, likely due to the ability of cells to better cluster receptors on these surfaces.
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