2024 article

Utilizing multiscale engineered biomaterials to examine TGF-β-mediated myofibroblastic differentiation

Simpson, A., Krissanaprasit, A., Chester, D., Koehler, C., Labean, T. H., & Brown, A. C. (2024, March 9). WOUND REPAIR AND REGENERATION.

By: A. Simpson n, A. Krissanaprasit n, D. Chester n, C. Koehler n, T. Labean n & A. Brown n

author keywords: biomaterials; DNA origami; fibrosis; mechanotransduction; microgel; TGF-beta
TL;DR: It is found that highly viscous materials with non-fixed TGF-β-R spacing promoted increased TGF-β signalling and myofibroblastic differentiation, likely due to the ability of cells to better cluster receptors on these surfaces. (via Semantic Scholar)
Source: Web Of Science
Added: March 18, 2024

Abstract