2019 journal article

Driving the Scalability of DNA-Based Information Storage Systems

ACS SYNTHETIC BIOLOGY, 8(6), 1241–1248.

By: K. Tomek n, K. Volkel n, A. Simpson n, A. Hass n, E. Indermaur n, J. Tuck n , A. Keung n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: synthetic biology; DNA storage; information storage; nested architecture; file access; DNA sequencing
MeSH headings : DNA / chemistry; DNA / genetics; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Information Storage and Retrieval / methods; Sequence Analysis, DNA / methods; Synthetic Biology / methods
Source: Web Of Science
Added: July 15, 2019

The extreme density of DNA presents a compelling advantage over current storage media; however, to reach practical capacities, new systems for organizing and accessing information are needed. Here, we use chemical handles to selectively extract unique files from a complex database of DNA mimicking 5 TB of data and design and implement a nested file address system that increases the theoretical maximum capacity of DNA storage systems by five orders of magnitude. These advancements enable the development and future scaling of DNA-based data storage systems with modern capacities and file access capabilities.