2008 journal article

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Failure to replicate effect of Kibra on human memory in two large cohorts of European origin

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 147B(5), 667–668.

By: A. Need ^*, D. Attix ^*, J. McEvoy^*, E. Cirulli ^*, K. Linney^*, A. Wagoner ⁿ, C. Gumbs ^*, I. Giegling ^* ...and 8 other authors, including 1 NC State author, H. Moeller, C. Francks ^*, P. Muglia ^*, A. Roses^*, G. Gibson ⁿ, M. Weale ^*, D. Rujescu ^*, D. Goldstein ^*

author keywords: neurocognition; phenotype; cognitive task; replication; neurogenetics

MeSH headings : Cohort Studies; Europe; Humans; Intracellular Signaling Peptides and Proteins; Memory / physiology; Phosphoproteins; Polymorphism, Single Nucleotide; Proteins / genetics; Proteins / physiology; Reproducibility of Results; White People

TL;DR: It is suggested that Kibra does not have a strong and general effect on human memory. (via Semantic Scholar)

10.1002/ajmg.b.30658

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Added: August 6, 2018

AbstractIt was recently suggested that the Kibra polymorphism rs17070145 has a strong effect on multiple episodic memory tasks in humans. We attempted to replicate this using two cohorts of European genetic origin (n = 319 and n = 365). We found no association with either the original SNP or a set of tagging SNPs in the Kibra gene with multiple verbal memory tasks, including one that was an exact replication (Auditory Verbal Learning Task, AVLT). These results suggest that Kibra does not have a strong and general effect on human memory. © 2008 Wiley‐Liss, Inc.