2020 review

Parahydrogen-Induced Hyperpolarization of Gases

[Review of ]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(41), 17788–17797.

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 Russian Federation 🇷🇺 United States of America 🇺🇸
author keywords: hyperpolarization; MRI; NMR; parahydrogen; spectroscopy
MeSH headings : Catalysis; Gases / chemistry; Hydrogen / chemistry; Magnetic Resonance Imaging / methods; Magnetic Resonance Spectroscopy / methods
Source: Web Of Science
Added: August 31, 2020

Abstract Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen‐induced polarization is a fast, highly scalable, and low‐cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen‐induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.