2020 journal article
Multi-layer dressing made of laminated electrospun nanowebs and cellulose-based adhesive for comprehensive wound care
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 162, 629–644.
author keywords: Multi-layer wound dressing; Graft copolymerization; Encapsulation; Electrospinning
MeSH headings : Animals; Bandages; Cell Line; Cellulose / chemistry; Cellulose / pharmacology; Fibroblasts / metabolism; Fibroblasts / pathology; Gentamicins / chemistry; Gentamicins / pharmacology; Humans; Male; Materials Testing; Nanofibers / chemistry; Rats; Tissue Adhesives / chemistry; Tissue Adhesives / pharmacology; Wounds and Injuries / metabolism; Wounds and Injuries / pathology; Wounds and Injuries / therapy
TL;DR:
Biocompatibility test showed insignificant adverse effects of the fabricated layers on fibroblast cells, and Histopathological findings corroborated the intactness of the epidermis layer of the treated samples.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 2, 2020
In this work, multi-layer wound dressing was made of laminated layers of electrospun fibers supported by adhesive sheet. Graft copolymerization of methyl methacrylate (MMA) and 2-Ethyl-1-hexyl acrylate (EHA) onto carboxymethyl cellulose (CMC) was conducted to obtain an adhesive sheet with 1.52 (N/cm 2 ) loop tack, 1.7 (N/cm) peel strength and 25 s shear strength. Diclofenac sodium, anti-inflammatory drug, was loaded to the adhesive sheet with encapsulation efficiency 73%. The contact layer to wound was made of synthesized anti-bleeding agents, chitosan iodoacetamide (CI) loaded into electrospun polyvinyl alcohol (PVA) fibers. It was fabricated from fiber diameter 300 nm by electrospinning of 5% wt/v of CI (D.S. 18.7%) mixed with 10% wt/v PVA, at 20 kV and 17 cm airgap. The second, pain-relief layer was fabricated by encapsulating up to 50% wt/wt of capsaicin into gelatin nanofibers (197 nm) crosslinked by glyoxal. The third, antimicrobial layer was fabricated from PVA electrospun fibers loaded with 2% wt/wt gentamicin. Biocompatibility test showed insignificant adverse effects of the fabricated layers on fibroblast cells. Animal test on rat showed accelerated wound healing from 21 to 7 days for the multi-layer dressing. Histopathological findings corroborated the intactness of the epidermis layer of the treated samples.