1997 journal article
Requirement of heme to replace the sparking sterol function in the yeast Saccharomyces cerevisiae
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1345(1), 71–76.
author keywords: Delta(5)-sterol; heme auxotrophy; sparking sterol; ergosterol; (Saccharomyces cerevisiae)
MeSH headings : Aminolevulinic Acid / metabolism; Ergosterol / metabolism; Heme / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / growth & development; Sterols / biosynthesis
TL;DR:
It is demonstrated here that heme, and not a heme precursor, can replace the delta 5-sparking sterol requirement of heme auxotrophic strains of yeast.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
At least four distinctive sterol functions have been defined in the yeast Saccharomyces cerevisiae. One of these functions, identified as sparking, has the lowest quantitative requirement for sterol, but has the greatest structural specificity. Based on studies utilizing a yeast strain auxotrophic for both heme and sterol biosynthesis, it had been reported that a delta 5-sterol was essential for the growth of the organism. We demonstrate here that heme, and not a heme precursor, can replace the delta 5-sparking sterol requirement of heme auxotrophic strains of yeast.