2012 journal article

Modelling transport of layered double hydroxide nanoparticles in axons and dendrites of cortical neurons

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 15(12), 1263–1271.

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: nanoparticle transport; neurons; axons and dendrites; nanomedicine; molecular motors; fast axonal transport
MeSH headings : Axonal Transport / physiology; Axons / metabolism; Cerebral Cortex / cytology; Cerebral Cortex / metabolism; Computer Simulation; Dendrites / metabolism; Drug Delivery Systems; Humans; Microtubules / metabolism; Models, Neurological; Nanoparticles / administration & dosage; Nanotechnology; Neurons / metabolism; Transport Vesicles / metabolism
Source: Web Of Science
Added: August 6, 2018

This paper develops a model of nanoparticle transport in neurons. It is assumed that nanoparticles are transported inside endocytic vesicles by a combined effect of dynein-driven transport and diffusion. It is further assumed that in axons nanoparticles are internalised only at axon terminals, whereas in dendrites nanoparticles can enter through the entire plasma membrane. This causes differences in transport of nanoparticles in axons and dendrites; these differences are investigated in this paper. Another difference is microtubule (MT) orientation in axons and dendrites; in axons, all MTs have their plus-ends oriented towards the axon terminal; in a proximal region of a dendrite, MTs have mixed orientation, whereas in a distal dendritic region the MT orientation is similar to that in an axon. It is shown that if molecular-motor-driven transport were powered by dynein alone, such MT orientation in a dendrite would result in a region of nanoparticle accumulation located at the border between the proximal and distal dendritic regions.