2013 journal article

An analytical solution describing the propagation of positive injury signals in an axon: effect of dynein velocity distribution

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 16(7), 699–706.

co-author countries: United States of America 🇺🇸
author keywords: neuronal injury; positive injury signals; motor-dependent signals; dynein motors; retrograde axonal transport
MeSH headings : Animals; Axonal Transport / physiology; Axons / metabolism; Axons / physiology; Dyneins / metabolism; Models, Neurological; Neurons / metabolism; Neurons / physiology
Source: Web Of Science
Added: August 6, 2018

A model describing the propagation of positive injury signals from the lesion site in an axon towards the neuron soma is described. It is assumed that these signals are driven by dynein molecular motors. An analytical solution that accounts for the probability density function (pdf) of a dynein velocity distribution is obtained. Two examples of pdf of dynein velocity distributions that follow from the results published in Ross et al. (2006, Processive bidirectional motion of dynein–dynactin complexes in vitro. Nat Cell Biol. 8:562–570) and Deinhardt et al. (2006, Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 52:293–305) are considered. The effect of dynein velocity distribution on the rate of spreading of the signal wave is discussed. It is demonstrated that the obtained solution can be applied to the problem of how neurons measure the distance between the lesion site and the neuron soma.