2021 journal article
Dynamic Surfaces—Degradable Polyester Networks that Resist Protein Adsorption
Langmuir, 7.
MeSH headings : Adsorption; Hydrophobic and Hydrophilic Interactions; Kinetics; Polyesters; Serum Albumin, Bovine
TL;DR:
A series of novel degradable alternating copolyesters composed of diglycolic anhydride and two epoxides and a photoactive crosslinking agent are synthesized, finding the lower gel fraction networks possess a higher swelling ratio and resist bovine serum albumin adsorption better by entropic shielding and faster degradation.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: July 24, 2021
We synthesized a series of novel degradable alternating copolyesters composed of diglycolic anhydride (DGA) and two epoxides, epoxymethoxytriethylene glycol (ETEG) and a photoactive crosslinking agent epoxy benzophenone (EBP). After UV crosslinking, soaking the films in a good solvent (tetrahydrofuran) removed uncrosslinked material, and the resulting film gel fractions were calculated. These network films were then degraded in buffer solutions of varying pH values. The degradation of networks with lower gel fraction (fewer crosslinks) was faster and followed first-order kinetics. In contrast, the denser network degraded slower and followed zeroth-order kinetics. The lower gel fraction networks possess a higher swelling ratio and resist bovine serum albumin (BSA) adsorption better by entropic shielding and faster degradation. In comparison, higher gel fraction networks with higher EBP mole fractions adsorb more BSA due to hydrophobic interactions and slower degradation.