2021 article

On the Use of Z-Scores for Fine-Mapping with Related Individuals

Jiang, J. (2021, October 13). (Vol. 10). Vol. 10.

By: J. Jiang n 

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
Source: ORCID
Added: February 1, 2022

Abstract Using summary statistics from genome-wide association studies (GWAS) has been widely used for fine-mapping complex traits in humans. The statistical framework was largely developed for unrelated samples. Though it is possible to apply the framework to fine-mapping with related individuals, extensive modifications are needed. Unfortunately, this has often been ignored in summary-statistics-based fine-mapping with related individuals. In this paper, we show in theory and simulation what modifications are necessary to extend the use of summary statistics to related individuals. The analysis also demonstrates that though existing summary-statistics-based fine-mapping methods can be adapted for related individuals, they appear to have no computational advantage over individual-data-based methods.