2021 journal article
Reduced Endometrial Ascension and Enhanced Reinfection Associated With Immunoglobulin G Antibodies to Specific Chlamydia trachomatis Proteins in Women at Risk for Chlamydia
JOURNAL OF INFECTIOUS DISEASES, 225(5), 846–855.
author keywords: Chlamydia; genital tract; antibody; serology; endometrium; immunoproteome
MeSH headings : Antibodies, Bacterial; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Immunoglobulin G; Reinfection
TL;DR:
Protein-specific CT antibodies are not sufficient to protect against ascending or incident infection but broad recognition of CT proteins by IgG correlates with cervical CT gene transcript abundance, suggesting CT protein abundance correlates with immunogenicity and signifies their potential as vaccine candidates.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 21, 2022
Abstract Background Previous research revealed antibodies targeting Chlamydia trachomatis elementary bodies was not associated with reduced endometrial or incident infection in C. trachomatis–exposed women. However, data on the role of C. trachomatis protein–specific antibodies in protection are limited. Methods A whole-proteome C. trachomatis array screening serum pools from C. trachomatis–exposed women identified 121 immunoprevalent proteins. Individual serum samples were probed using a focused array. Immunoglobulin (Ig) G antibody frequencies and endometrial or incident infection relationships were examined using Wilcoxon rank sum test. The impact of the breadth and magnitude of protein-specific IgGs on ascension and incident infection were examined using multivariable stepwise logistic regression. Complementary RNA sequencing quantified C. trachomatis gene transcripts in cervical swab samples from infected women. Results IgG to pGP3 and CT_005 were associated with reduced endometrial infection; anti-CT_443, anti–CT_486, and anti–CT_123 were associated with increased incident infection. Increased breadth of protein recognition did not however predict protection from endometrial or incident infection. Messenger RNAs for immunoprevalent C. trachomatis proteins were highly abundant in the cervix. Conclusions Protein-specific C. trachomatis antibodies are not sufficient to protect against ascending or incident infection. However, cervical C. trachomatis gene transcript abundance positively correlates with C. trachomatis protein immunogenicity. These abundant and broadly recognized antigens are viable vaccine candidates.