2022 article

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis

Pike, C. M., Tam, J., Melnyk, R. A., & Theriot, C. M. (2022, July 7). INFECTION AND IMMUNITY.

By: C. Pike n, J. Tam *, R. Melnyk * & C. Theriot n

author keywords: Clostridioides difficile; apoptosis; bile acids; tauroursodeoxycholic acid; toxin; ursodeoxycholic acid
MeSH headings : Anti-Bacterial Agents / pharmacology; Antibodies, Bacterial / pharmacology; Apoptosis; Bile Acids and Salts / pharmacology; Caco-2 Cells; Clostridioides difficile; Clostridium Infections / microbiology; Humans; Inflammation; Taurochenodeoxycholic Acid; Ursodeoxycholic Acid / pharmacology
TL;DR: It is demonstrated that bile acid conjugation can have profound effects on C. difficile as well as the host and that conjugated and unconjugated bile acids may exert different therapeutic mechanisms against CDI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 26, 2022

C. difficile infection (CDI) is a highly inflammatory disease mediated by the production of two large toxins that weaken the intestinal epithelium and cause extensive colonic tissue damage. Antibiotic alternative therapies for CDI are urgently needed as current antibiotic regimens prolong the perturbation of the microbiota and lead to high disease recurrence rates.