2022 journal article

Epidemiology of Plasmid Lineages Mediating the Spread of Extended-Spectrum Beta-Lactamases among Clinical Escherichia coli

MSystems.

By: B. Mahmud, M. Wallace*, K. Reske *, K. Alvarado*, C. Muenks *, D. Rasmussen  n, C. Burnham *, C. Lanzas n , E. Dubberke *, G. Dantas *

Ed(s): C. Marshall

author keywords: Escherichia coli; beta-lactamases; plasmid-mediated resistance
MeSH headings : Humans; Escherichia coli / genetics; Escherichia coli Infections / epidemiology; beta-Lactamases / genetics; Plasmids / genetics; Hospitals
TL;DR: This work provides a detailed picture of plasmid-mediated spread of ESBLs, demonstrating the extensive sequence diversity within identified lineages, while highlighting the genetic elements that underlie the persistence of these plasmids within the clinical E. coli population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: August 24, 2022

The increasing incidence of nosocomial infections with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli represents a significant threat to public health, given the limited treatment options available for such infections. The rapid ESBL spread is suggested to be driven by localization of the resistance genes on conjugative plasmids.