2023 journal article
Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling
Allergy.
author keywords: asthma; IgE; mast cells
MeSH headings : Animals; Humans; Mice; Basophils / metabolism; Cell Degranulation; Exons; Hypersensitivity / metabolism; Mast Cells / metabolism; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction
TL;DR:
It is reported that targeting FcεRIβ with exon‐skipping oligonucleotides eliminates IgE‐mediated degranulation in mouse MCs, but equivalent targeting in human MCs was not effective at reducing degranulations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 25, 2022
Abstract