2018 journal article

Important signals regulating coronary artery angiogenesis

MICROVASCULAR RESEARCH, 117, 1–9.

By: S. Shoeibi*, P. Mozdziak n & S. Mohammadi*

co-author countries: Iran (Islamic Republic of) 🇮🇷 United States of America 🇺🇸
author keywords: Angiogenesis; Growth factor; Intraplaque
MeSH headings : Angiogenesis Inhibitors / therapeutic use; Angiogenic Proteins / metabolism; Animals; Cell Communication; Cell Differentiation; Cell Movement; Cell Proliferation; Coronary Artery Disease / drug therapy; Coronary Artery Disease / metabolism; Coronary Artery Disease / pathology; Coronary Artery Disease / physiopathology; Coronary Vessels / drug effects; Coronary Vessels / metabolism; Coronary Vessels / pathology; Coronary Vessels / physiopathology; Humans; Neovascularization, Pathologic; Plaque, Atherosclerotic; Signal Transduction
Source: Web Of Science
Added: August 6, 2018

Angiogenesis is a complex process of budding, the formation of new blood vessels from pre-existing microvessels, via migration, proliferation and survival. Vascular angiogenesis factors include different classes of molecules that have a fundamental role in blood vessel formation. Numerous inducers of angiogenesis, such as the members of the vascular endothelial growth factor (VEGF) family, basic fibroblast growth factor (bFGF), angiopoietin (Ang), hepatocyte growth factor (HGF), and hypoxia inducible factor-1 (HIF-1), have an important role in angiogenesis. However, VEGF, platelet-derived growth factor (PDGF), and transforming growth factor β (TGF-β) expression appear to be important in intraplaque angiogenesis. Interaction and combined effects between growth factors is essential in endothelial cell migration, proliferation, differentiation, and endothelial cell-cell communication that ultimately lead to the microvessel formation. Since VEGF has a key role during angiogenesis; it may be considered as a good therapeutic target in the clinic. The essential function of several angiogenic factors involved in coronary angiogenesis and intraplaque angiogenesis in atherosclerosis are carefully considered along with the use of angiogenic factors in clinical practice.