2022 journal article

Cite it

A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

Science, 376(6596), 1006–1012.

By: Y. Choi ^*, H. Jeong ^*, R. Yin ^*, R. Avila ^*, A. Pfenniger ^*, J. Yoo ^*, J. Lee ^*, A. Tzavelis ^* ...and 41 other authors, including 1 NC State author, Y. Lee ^*, S. Chen ^*, H. Knight ^*, S. Kim ^*, H. Ahn ^*, G. Wickerson ^*, A. Vázquez-Guardado^* , E. Higbee-Dempsey ^*, B. Russo ^*, M. Napolitano ^*, T. Holleran ^*, L. Razzak ^*, A. Miniovich^*, G. Lee ^*, B. Geist ^*, B. Kim^*, S. Han^*, J. Brennan^*, K. Aras ^*, S. Kwak ^*, J. Kim ^*, E. Waters ^*, X. Yang ^*, A. Burrell ^*, K. Chun ^*, C. Liu ^*, C. Wu ^*, A. Rwei ^*, A. Spann ^*, A. Banks ^*, D. Johnson ^*, Z. Zhang ^*, C. Haney ^*, S. Jin ^*, A. Sahakian ^*, Y. Huang ^*, G. Trachiotis^*, B. Knight ^*, R. Arora ^*, I. Efimov ^*, J. Rogers ^*(hide authors)

Contributors: Y. Choi ^*, H. Jeong ^*, R. Yin ^*, R. Avila ^*, A. Pfenniger ^*, J. Yoo ^*, J. Lee ^*, A. Tzavelis ^* ...and 41 other authors, including 1 NC State author, Y. Lee ^*, S. Chen ^*, H. Knight ^*, S. Kim ^*, H. Ahn ^*, G. Wickerson ^*, A. Vázquez-Guardado^* , E. Higbee-Dempsey ^*, B. Russo ^*, M. Napolitano ^*, T. Holleran ^*, L. Razzak ^*, A. Miniovich^*, G. Lee ^*, B. Geist ^*, B. Kim^*, S. Han^*, J. Brennan^*, K. Aras ^*, S. Kwak ^*, J. Kim ^*, E. Waters ^*, X. Yang ^*, A. Burrell ^*, K. Chun ^*, C. Liu ^*, C. Wu ^*, A. Rwei ^*, A. Spann ^*, A. Banks ^*, D. Johnson ^*, Z. Zhang ^*, C. Haney ^*, S. Jin ^*, A. Sahakian ^*, Y. Huang ^*, G. Trachiotis^*, B. Knight ^*, R. Arora ^*, I. Efimov ^*, J. Rogers ^*(hide authors)

MeSH headings : Absorbable Implants; Animals; Cardiac Pacing, Artificial; Dogs; Heart Rate; Humans; Pacemaker, Artificial; Postoperative Care / instrumentation; Rats; Wireless Technology

TL;DR: This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices and provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. (via Semantic Scholar)

10.1126/science.abm1703

Find Text @ NCSU

open access via resolver.tudelft.nl (repository)

PubMed

Source: ORCID

Added: March 14, 2023

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.