2024 article
The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses
Bello, K., Lorch, G., Papich, M. G., Kim, K., Toribio, R. E., Yan, L., … Phelps, M. A. (2024, February 9). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS.
author keywords: equine; fed vs. fasted; immune-mediated; mycophenolate mofetil; pharmacokinetics
TL;DR:
Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single-dose MMF administration but may be significant in horses receiving long-term MMF treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 19, 2024
AbstractAdditional immunomodulatory treatment is needed for the management of immune‐mediated disease in horses. Mycophenolate mofetil (MMF) is an immunomodulatory agent used in human and veterinary medicine for the prevention of graft rejection and the management of autoimmune diseases. Few studies exist investigating the pharmacokinetics of MMF in horses. The aim of this study was to evaluate the pharmacokinetics of a single dose of MMF in healthy horses in the fed vs. fasted state. Six healthy Standardbred mares were administered MMF 10 mg/kg by a nasogastric (NG) tube in a fed and fasted state. A six‐day washout period was performed between the two doses. No statistically significant differences in mycophenolic acid (MPA) concentrations were seen at any time point apart from 8 h, when plasma metabolite concentrations were significantly higher in the fasted state compared to the fed state (p = .038). Evidence of enterohepatic recirculation was seen only in the fasted state; this did not yield clinical differences in horses administered a single‐dose administration but may be significant in horses receiving long‐term MMF treatment.