2024 journal article

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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells

CELLS, 13(20).

By: A. Romani ^*, G. Lodi^*, F. Casciano ^*, A. Gonelli ^*, P. Secchiero ^*, G. Zauli ^*, O. Bortolini ^*, G. Valacchi^*  ...and 5 other authors, D. Ragno ^*, A. Bondi^*, M. Benedusi ^*, E. Esposito ^* & R. Voltan ^*

author keywords: nanodelivery; ethosomes; nutlin-3a; MDM2 inhibitors; cell cycle; p53; Notch-1; melanoma

10.3390/cells13201678

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open access via doi.org (publisher)

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1. No Poverty (OpenAlex)

Source: Web Of Science

Added: November 4, 2024

This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility, limiting its bio-distribution and therapeutic efficacy. The potential of nutlin-3a-loaded ethosomes was investigated on two in vitro models of melanoma: the HT144 cell line p53