2024 journal article

Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells

CELLS, 13(20).

author keywords: nanodelivery; ethosomes; nutlin-3a; MDM2 inhibitors; cell cycle; p53; Notch-1; melanoma
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Source: Web Of Science
Added: November 4, 2024

This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility, limiting its bio-distribution and therapeutic efficacy. The potential of nutlin-3a-loaded ethosomes was investigated on two in vitro models of melanoma: the HT144 cell line p53