Digital textile printing (DTP) is fast, flexible, and relatively inexpensive for sample printing, and can be applied quickly in response to consumer demand. The aim of this two-stage research was to analyze the potential of DTP to replace traditional screen printing for a specific textile product. In Stage One, an optimal DTP workflow was established. The workflow included determination of the colorant and substrate combination, color calibration, CAD file, and the necessity of pretreatment. In Stage Two, a visual assessment instrument and protocol were established to evaluate the acceptance of replicated ink-jet printed fabric. The visual assessment and protocol were designed to evaluate the acceptance of the ink-jet printed sample to fully replicate the screen-printed sample via seven measured aspects. These seven aspects include: perceived color difference, lightness difference, overall color, scale, line quality, visual texture, and overall appearance. Data gathered from the visual assessment was then analyzed and compared using SPSS statistics software. The results indicate that DTP demonstrates a significant potential alternative for traditional screen printing.