Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains
GENETICS, 213(3), 1079–1092.
author keywords: ischemic stroke; wild-derived mouse strains; neuroprotection; quantitative trait mapping
MeSH headings : Animals; Female; Genetic Predisposition to Disease; Inbreeding; Infarction, Middle Cerebral Artery / genetics; Male; Mice; Polymorphism, Single Nucleotide; Quantitative Trait Loci
TL;DR:
This study expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ, that breaks this general rule that collateral vessel density inversely correlates with infarct volume.
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