2020 journal article
Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers
PARASITES & VECTORS, 13(1).
author keywords: Alpha-gal; Amblyomma americanum; Red meat allergy
MeSH headings : Adult; Amblyomma / immunology; Amblyomma / physiology; Animals; Cattle; Disaccharides / immunology; Farmers; Female; Food Hypersensitivity / blood; Food Hypersensitivity / etiology; Food Hypersensitivity / immunology; Humans; Immunoglobulin E / blood; Immunoglobulin E / immunology; Male; Middle Aged; North Carolina; Prospective Studies; Red Meat / adverse effects; Tick Bites / complications; Tick Bites / immunology; Tick Bites / parasitology
TL;DR:
The results support the role of A. americanum bites and increased sensitization to alpha-gal as likely agents for eliciting an allergic response to red meat, and highlight the importance of preventing tick bites.
(via Semantic Scholar)
open access via parasitesandvectors.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
Abstract Background Alpha-gal is an oligosaccharide implicated in delayed anaphylaxis following red meat consumption. Exposure to tick bites has been correlated with development of an allergic response to alpha-gal. However, evidence prospectively linking exposure to a single tick species and an immune response to alpha-gal is lacking. Methods We used serum samples from a prior study cohort of outdoor workers in North Carolina, USA, with high exposure to the lone star tick, Amblyomma americanum, to prospectively evaluate the relationship between tick bites and anti-alpha-gal IgE antibodies. Results Individuals who reported exposure to one or more tick bites were significantly more likely to have a positive change in anti-alpha-gal IgE compared to individuals with no reported tick bites. This relationship was not dependent on time. A trend toward increasing number of tick bites and increased anti-alpha-gal IgE levels was observed but not statistically significant. Conclusion To our knowledge, this is the first study to prospectively link documented exposure to A. americanum bites and increased sensitization to alpha-gal in a cohort of outdoor workers. Our results support the role of A. americanum as likely agents for eliciting an allergic response to red meat, and highlight the importance of preventing tick bites.