2021 journal article

The role of NO in COVID-19 and potential therapeutic strategies

Free Radical Biology and Medicine, 163, 153–162.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: COVID-19; Nitric oxide; Vasodilation; Anti-viral; Anti-inflammation
MeSH headings : Administration, Inhalation; Anti-Inflammatory Agents / blood; Anti-Inflammatory Agents / therapeutic use; Anticoagulants / blood; Anticoagulants / therapeutic use; Antiviral Agents / blood; Antiviral Agents / therapeutic use; COVID-19 / blood; COVID-19 / pathology; COVID-19 / virology; Endothelial Cells / drug effects; Endothelial Cells / pathology; Endothelial Cells / virology; Humans; Inflammation; Lung / blood supply; Lung / drug effects; Lung / virology; Mitochondria / drug effects; Mitochondria / virology; Nitric Oxide / blood; Nitric Oxide / therapeutic use; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity; Severity of Illness Index; Vasodilation / drug effects; COVID-19 Drug Treatment
Source: Crossref
Added: February 6, 2021

Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.