Metabolic source isotopic pair labeling and genome-wide association are complementary tools for the identification of metabolite–gene associations in plants
The Plant Cell.
MeSH headings : Arabidopsis / genetics; Arabidopsis / metabolism; Genome-Wide Association Study / methods; Isotope Labeling; Mass Spectrometry; Metabolome / genetics; Metabolome / physiology; Metabolomics / methods; Retrospective Studies
TL;DR:
Overall, it is shown that cataloguing a biochemical pathway's products through isotopic labeling across genetic variants can substantially contribute to the identification of metabolites and genes associated with their biosynthesis.
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