2014 journal article

Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems

CARBOHYDRATE POLYMERS, 100, 166–178.

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Silver nanoparticles; Chitosan; Electrospinning; Antimicrobial; Polyvinyl alcohol
MeSH headings : Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bandages / microbiology; Chitosan / chemistry; Drug Carriers / chemistry; Escherichia coli / drug effects; Glucose / chemistry; Green Chemistry Technology; Metal Nanoparticles / chemistry; Nanofibers / chemistry; Polyvinyl Alcohol / chemistry; Reducing Agents / chemistry; Silver / chemistry; Silver Nitrate / chemistry; Temperature; Wounds and Injuries
Source: Web Of Science
Added: August 6, 2018

Novel hybrid nanomaterials have been developed for antimicrobial applications. Here we introduce a green route to produce antibacterial nanofiber mats loaded with silver nanoparticles (Ag-NPs, 25 nm diameter) enveloped in chitosan after reduction with glucose. The nanofiber mats were obtained from colloidal dispersions of chitosan-based Ag-NPs blended with polyvinyl alcohol. Nanofibers (150 nm average diameter and narrow size distribution) were obtained by electrospinning and cross-linked with glutaraldhyde. The effect of crosslinking on the release of silver was studied by atomic absorption spectroscopy. Antimicrobial activity was studied by the viable cell-counting; mats loaded with silver and control samples (chitosan/PVA) with different degrees of cross-linking were compared for their effectiveness in reducing or halting the growth of aerobic bacteria. The results showed superior properties and synergistic antibacterial effects by combining chitosan with Ag-NPs.