2021 journal article

Stereoselective Synthesis of the Spirocyclic γ-Lactam Core of the Ansalactams

Organic Letters, 11.

By: Z. Liang n, Y. Lin n & J. Pierce n

co-author countries: United States of America 🇺🇸
MeSH headings : Spiro Compounds
Source: ORCID
Added: December 1, 2021

Ansalactam A is an ansa macrolide natural product that contains a densely functionalized spiro-γ-lactam core containing three contiguous stereocenters. This unusual motif distinguishes it from other members of this family and represents a significant synthetic challenge. Herein, we report the development of a stereoselective formal [3+2] cycloaddition reaction for the construction of this key spiro-γ-lactam motif for the first time, thereby enabling access to the northern domain of ansalactam A.