2018 journal article
Interaction of Copper Toxicity and Oxidative Stress in Campylobacter jejuni
Journal of Bacteriology, 200(21).
Ed(s): V. DiRita
author keywords: Campylobacter; copper
MeSH headings : Animal Feed / analysis; Animal Feed / toxicity; Animals; Bacterial Proteins / genetics; Campylobacter jejuni / drug effects; Campylobacter jejuni / genetics; Campylobacter jejuni / metabolism; Chickens; Copper / toxicity; Copper Sulfate / toxicity; Mutation; Oxidation-Reduction; Oxidative Stress; Oxidoreductases / genetics
TL;DR:
The results indicate that copper toxicity in C. jejuni is due to a failure to effectively sequester cytoplasmic copper, resulting in an increase in copper-mediated oxidative damage.
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open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
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Added: April 4, 2022
Copper is a required micronutrient for most aerobic organisms, but it is universally toxic at elevated levels. These organisms use homeostatic mechanisms that allow for cells to acquire enough of the element to sustain metabolic requirements while ensuring that lethal levels cannot build up in the cell. Campylobacter jejuni is an important foodborne pathogen that typically makes its way into the food chain through contaminated poultry. C. jejuni has a metabolic requirement for copper and encodes a copper detoxification system. In the course of studying this system, we have learned that it is important for avian colonization. We have also gained insight into how copper exerts its toxic effects in C. jejuni by promoting oxidative stress.