Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 119 (18).
By: L. Tse * , R. Meganck * , K. Araba* , B. Yount * , K. Shaffer * , Y. Hou * , J. Munt * , L. Adams * ...and 8 other authors, including 2 NC State authors , J. Wykoff * , J. Morowitz* , S. Dong * , S. Magness n , W. Marzluff * , L. Gonzalez n , C. Ehre * , R. Baric *
author keywords: PLAC8; coronavirus; CRISPR; swine acute diarrhea syndrome coronavirus
MeSH headings : Alphacoronavirus / genetics; Animals; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; Coronavirus Infections / epidemiology; Swine; Swine Diseases
TL;DR:
Using genomewide CRISPR knockout screening, the placenta-associated 8 protein (PLAC8) is identified as an essential host factor for SADS-CoV infection, uncovering a novel antiviral target for CoV infection.
(via
Semantic Scholar )
UN Sustainable Development Goal Categories