2022 journal article
Variation in upstream open reading frames contributes to allelic diversity in maize protein abundance
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(14).
author keywords: uORF; proteome; rare alleles; maize; gene expression
MeSH headings : 5' Untranslated Regions; Open Reading Frames / genetics; Protein Biosynthesis / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Ribosomes / genetics; Ribosomes / metabolism; Zea mays / genetics; Zea mays / metabolism
TL;DR:
It is found that rare variants near the start codon of uORFs can repress or derepress mORF translation, causing allelic changes in protein abundance and providing evidence for the mechanisms by which natural sequence variation modulates gene expression, and ultimately, phenotype.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 11, 2022
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