2023 journal article

TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells

Toxicological Sciences.

author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
TL;DR: A global transcriptomic landscape during early, intermediate, and apical stages of osteogenic differentiation in vitro in response to TCDD is established to identify novel pathways and transcription factors that may facilitate a better understanding of the osteoblast differentiation process, perturbation by exogenous agents, and potential intervention strategies targeting those specific pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: December 1, 2022