2023 article

ATP diffusional gradients are sufficient to maintain bioenergetic homeostasis in synaptic boutons lacking mitochondria

Kuznetsov, I. A., & Kuznetsov, A. V. (2023, March 5). INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING.

By: I. Kuznetsov * & A. Kuznetsov n

author keywords: ATP; axons; diffusion-driven transport; mathematical modeling; mitochondria
MeSH headings : Presynaptic Terminals / metabolism; Axons; Energy Metabolism; Mitochondria / metabolism; Adenosine Triphosphate / metabolism
TL;DR: This work develops and applies a mathematical model to study whether diffusive transport of ATP is sufficient to support the exocytic functionality in synaptic boutons which lack mitochondria, and demonstrates that it is. (via Semantic Scholar)
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Source: Web Of Science
Added: March 20, 2023

AbstractPrevious work on mitochondrial distribution in axons has shown that approximately half of the presynaptic release sites do not contain mitochondria, raising the question of how the boutons that do not contain mitochondria are supplied with ATP. Here, we develop and apply a mathematical model to study this question. Specifically, we investigate whether diffusive transport of ATP is sufficient to support the exocytic functionality in synaptic boutons which lack mitochondria. Our results demonstrate that the difference in ATP concentration between a bouton containing a mitochondrion and a neighboring bouton lacking a mitochondrion is only approximately 0.4%, which is still 3.75 times larger than the ATP concentration minimally required to support synaptic vesicle release. This work therefore suggests that passive diffusion of ATP is sufficient to maintain the functionality of boutons which do not contain mitochondria.