Janice Benson Allen

Works (18)

Updated: February 10th, 2025 14:29

2006 journal article

NF-kappa B-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 290(1), G164–G174.

By: J. Gookin n , S. Chiang n, J. Allen n, M. Armstrong n, S. Stauffer n, C. Finnegan*, M. Murtaugh

author keywords: nitric oxide; barrier function; diarrhea; cryptosporidiosis
MeSH headings : Animals; Animals, Newborn; Body Weight; Chlorides / metabolism; Cryptosporidiosis / enzymology; Cryptosporidiosis / metabolism; Cryptosporidium parvum / immunology; Epithelial Cells / metabolism; Gene Expression Regulation, Enzymologic; Ileum / cytology; Ileum / metabolism; Ileum / ultrastructure; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; NF-kappa B / metabolism; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Swine; Swine Diseases / enzymology; Swine Diseases / metabolism; Swine Diseases / parasitology
TL;DR: It is shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function, suggesting that induction of i NOS represents a nonspecific response of the epithelium that mediates enterocyte defense against C. parvum infection. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Local peroxynitrite formation contributes to early control of Cryptosporidium parvum infection

INFECTION AND IMMUNITY, 73(7), 3929–3936.

By: J. Gookin n , J. Allen n, S. Chiang n, L. Duckett n & M. Armstrong n

MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum; Female; Immunohistochemistry; Lipid Peroxidation; Nitric Oxide Synthase / analysis; Nitric Oxide Synthase Type II; Peroxynitrous Acid / biosynthesis; Swine; Tyrosine / metabolism
TL;DR: The present results are the first to demonstrate an in vivo role for peroxynitrite formation in acute mucosal defense against a noninvasive intestinal epithelial pathogen. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells

Investigative Ophthalmology and Visual Science, 45(7), 2438–2446.

By: P. Yang, B. Mckay, J. Allen & G. Jaffe

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Effect of mutant I kappa B on cytokine-induced activation of NF-kappa B in cultured human RPE cells

Investigative Ophthalmology and Visual Science, 44(3), 1339–1347.

By: P. Yang, B. Mckay, J. Allen, W. Roberts & G. Jaffe

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells

AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(7), 942–947.

By: B. Gilger n , P. Yang  n, J. Salmon n, G. Jaffe  n & J. Allen n

MeSH headings : Animals; Aqueous Humor / metabolism; Chemokine CCL5 / biosynthesis; Chemokine CCL5 / genetics; Chemotaxis; Ciliary Body / cytology; Ciliary Body / metabolism; Epithelial Cells / metabolism; Female; Horse Diseases / metabolism; Horses; Male; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sequence Analysis, DNA; Uveitis / metabolism; Uveitis / veterinary
TL;DR: Ciliary epithelium may play a role in recruitment and activation of leukocytes through expression of RANTES in horses by use of intradermal hypersensitivity testing and significant chemotaxis of equine leukocyte to rh-RANTES. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Nitration of manganese superoxide dismutase during ocular inflammation

EXPERIMENTAL EYE RESEARCH, 74(4), 463–471.

By: K. Pittman n, L. MacMillan-Crow *, B. Peters n & J. Allen n

author keywords: uveitis; nitric oxide; peroxynitrite; nitration; MnSOD; albumin; reactive nitrogen species
MeSH headings : Acute Disease; Albumins / analysis; Animals; Eye Proteins / analysis; Female; Lipopolysaccharides; Peroxynitrous Acid / biosynthesis; RNA, Messenger / genetics; Rats; Rats, Inbred Lew; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Up-Regulation; Uveitis / chemically induced; Uveitis / enzymology
TL;DR: It is confirmed through immunoanalysis that nitrated proteins are produced during EIU, and furthermore, that MnS OD is a target of nitration during the inflammatory response, and two endogenous nitration targets, albumin and MnSOD, were identified. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 conference paper

Expression of inhibitory Smad7 in experimental uveitis

Journal of Leukocyte Biology, (2001), 71.

By: J. Allen & K. Pittman

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Use of an intravitreal sustained-release cyclosporine delivery device for treatment of equine recurrent uveitis

AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(12), 1892–1896.

By: B. Gilger n , D. Wilkie  n, M. Davidson n & J. Allen n

MeSH headings : Animals; Cyclosporine / administration & dosage; Delayed-Action Preparations; Electroretinography / veterinary; Female; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunosuppressive Agents / administration & dosage; Male; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
TL;DR: This intravitreal sustained-release CsA delivery device may be a safe and important tool for long-term treatment of horses with chronic recurrent uveitis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Effect of an intravitreal cyclosporine implant on experimental uveitis in horses

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 76(3-4), 239–255.

By: B. Gilger n , E. Malok n, T. Stewart n, D. Horohov*, P. Ashton, T. Smith, G. Jaffe *, J. Allen n

author keywords: uveitis; cyclosporine; intravitreal; equine; experimental
MeSH headings : Animals; Aqueous Humor / drug effects; Aqueous Humor / immunology; Aqueous Humor / metabolism; Cyclosporine / administration & dosage; Cyclosporine / immunology; Cyclosporine / pharmacokinetics; Drug Implants; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunohistochemistry / veterinary; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / immunology; Immunosuppressive Agents / pharmacokinetics; Interferon-gamma / biosynthesis; Interferon-gamma / metabolism; Interleukin-2 / biosynthesis; Interleukin-2 / metabolism; Lymphocyte Count / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Uveitis / drug therapy; Uveitis / immunology; Uveitis / veterinary
TL;DR: CsA implants did not completely eliminate the development of a second ('recurrent') experimental inflammatory episode in these horses, but the duration and severity of inflammation, cellular infiltration, tissue destruction, and pro-inflammatory cytokines RNA transcript levels were significantly less in those eyes implanted with the CsA device. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Ex vivo canine lens capsular sac explants

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 238(8), 708–714.

By: M. Davidson n, M. Wormstone *, D. Morgan n, R. Malakof n, J. Allen n & M. McGahan  n

MeSH headings : Actins / metabolism; Animals; Biomarkers; Cataract / metabolism; Cataract / pathology; Cell Division; Cells, Cultured; Dogs; Enzyme-Linked Immunosorbent Assay; Insulin-Like Growth Factor I / metabolism; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / growth & development; Lens Capsule, Crystalline / metabolism; Transferrin / metabolism; Transforming Growth Factor beta / metabolism; Transforming Growth Factor beta2; Vimentin / metabolism
TL;DR: Canine lens sac explants appear to be a useful alternative tissue source for this model when human cadaver eyes are unavailable and may influence the proliferation and metaplasia of LEC during the development of PCO. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Long-term effect on the equine eye of an intravitreal device used for sustained release of cyclosporine A

Veterinary Ophthalmology, 3(2), 105.

By: B. Gilger n , E. Malok n, T. Stewart n, P. Ashton, T. Smith, G. Jaffe*, J. Allen n

TL;DR: The CsA devices were well tolerated with no long-term complications from the implants themselves, however, complications may occur from inadvertent implantation trauma or contamination during surgery. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1999 journal article

Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 71(1), 17–28.

By: B. Gilger n , E. Malok n, K. Cutter n, T. Stewart n, D. Horohov* & J. Allen n

author keywords: equine; uveitis; T-lymphocyte; cytokines; immunohistochemistry; QRT-PCR
MeSH headings : Animals; Chronic Disease; Ciliary Body / immunology; Ciliary Body / pathology; Cytokines / biosynthesis; Cytokines / genetics; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Immunoenzyme Techniques / veterinary; Iris / immunology; Iris / pathology; RNA, Messenger / metabolism; Recurrence; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocyte Subsets / immunology; T-Lymphocytes / immunology; Uveitis, Anterior / immunology; Uveitis, Anterior / pathology; Uveitis, Anterior / veterinary
TL;DR: The QRT-PCR results revealed increased transcription of IL-2 and IFNgamma and low IL-4 mRNA expression in eyes with chronic ERU compared to normal eyes, demonstrating a Thelper (Th) 1-like inflammatory response in Eyes with ERU. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Suppression of NF-kappa B-Dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor

Investigative Ophthalmology and Visual Science, 40(2), 477–486.

By: X. Wang, C. Jobin, J. Allen, W. Roberts & G. Jaffe

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Nitric oxide and peroxynitrite production in ocular inflammation

Allen, J. B., Keng, T., & Privalle, C. (1998, October). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 106, pp. 1145–1149.

By: J. Allen n, T. Keng n & C. Privalle n

author keywords: nitric oxide; peroxynitrite; uveitis; SIN-1; SOD; inflammation; NOS inhibitors
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

The lens influences aqueous humor levels of transforming growth factor-beta 2

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 236(4), 305–311.

By: J. Allen*, M. Davidson n, M. Nasisse*, L. Fleisher* & M. McGahan

MeSH headings : Animals; Aphakia / etiology; Aphakia / metabolism; Aphakia / pathology; Aqueous Humor / metabolism; Biological Assay; Cataract / etiology; Cataract / metabolism; Cataract / pathology; Cells, Cultured; Ciliary Body / cytology; Ciliary Body / metabolism; Disease Models, Animal; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Male; Pigment Epithelium of Eye / cytology; Pigment Epithelium of Eye / metabolism; Rabbits; Transforming Growth Factor beta / metabolism
TL;DR: Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-β2 than their contralateral phakic controls, and that the presence and status of the lens may influence IOF TGF -β2 levels. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 chapter

Nitric oxide in ocular inflammation

In Advances in ocular toxicology (pp. 121–131).

By: J. Allen n, M. McGahan  n, L. Fleisher n, G. Jaffe * & C. Privalle

TL;DR: Differential competitive inhibition of isoforms of NOS by NG-substituted L-arginine analogues allows selective intervention to inhibit production of NO as well as to further determine its functions. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Intravitreal transforming growth factor-beta 2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits

CURRENT EYE RESEARCH, 15(1), 95–103.

By: J. Allen n, M. McGahan  n, Y. Ogawa, D. Sellon  n, B. Clark* & L. Fleisher n

author keywords: inflammation; in situ hybridization; rabbits; transforming growth factor-beta (TGF-beta); uveitis; endotoxin
MeSH headings : Animals; Anterior Eye Segment / pathology; Body Fluids / metabolism; Cell Movement / drug effects; Injections; Interleukin-1 / metabolism; Lipopolysaccharides; Male; Rabbits; Transforming Growth Factor beta / pharmacology; Uveitis / chemically induced; Uveitis / metabolism; Uveitis / pathology; Vitreous Body
TL;DR: In a rabbit model of LPS-induced uveitis, TGF-beta may interrupt the cascade of events leading to ocular inflammation, thereby suggesting therapeutic potential. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1996 journal article

Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis

EXPERIMENTAL EYE RESEARCH, 62(1), 21–28.

By: J. Allen n, M. McGahan  n, J. Ferrell n, K. Adler n & L. Fleisher n

author keywords: nitric oxide; uveitis; nitric oxide synthase; nitric oxide synthase inhibitors; inflammation
MeSH headings : Animals; Aqueous Humor / metabolism; Arginine / analogs & derivatives; Arginine / therapeutic use; Cell Count / drug effects; Dose-Response Relationship, Drug; Eye Proteins / drug effects; Guanidines / therapeutic use; Kinetics; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / physiology; Nitric Oxide Synthase / antagonists & inhibitors; Rabbits; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism; Uveitis, Anterior / prevention & control
TL;DR: Investigation of the effects of NOS inhibitors with different NOS isoform specificities in the rabbit model of endotoxin-induced ocular inflammation suggests that cNOS may play a greater role in the earlier stages of this developing inflammatory response, and extends others' observations that NO is a key mediator in uveitis. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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