Frank W. Leak

Works (3)

Updated: July 5th, 2023 16:04

1999 journal article

In yeast, upc2-1 confers a decrease in tolerance to LiCl and NaCl, which can be suppressed by the P-type ATPase encoded by ENA2

DNA AND CELL BIOLOGY, 18(2), 133–139.

By: F. Leak n, S. Tove* & L. Parks*

MeSH headings : Adenosine Triphosphatases / genetics; Cholesterol / pharmacokinetics; Dose-Response Relationship, Drug; Genes, Fungal / genetics; Genetic Complementation Test; Lithium Chloride / pharmacology; Mutation; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins; Sodium Chloride / pharmacology; Sterols / pharmacokinetics; Trans-Activators / genetics
TL;DR: Wild-type yeast cells are unable to take up sterols from their growth media under aerobic conditions and are relatively resistant to monovalent cations, but a yeast mutant with a defect in the aerobic exclusion of sterols was found to have increased sensitivity to LiCl and NaCl. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae

Journal of Bacteriology, 180(16), 4177–4183.

By: J. Crowley, F. Leak, K. Shianna, S. Tove & L. Parks

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae

CURRENT GENETICS, 32(2), 93–99.

By: L. Palermo n, F. Leak n, S. Tove n & L. Parks n

author keywords: ergosterol; ERG genes; yeast; Saccharomyces
MeSH headings : 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases / genetics; Ergosterol / biosynthesis; Genes, Fungal; Methyltransferases / genetics; Mutation; Oxidoreductases / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / growth & development; Saccharomyces cerevisiae / metabolism; Selection, Genetic
TL;DR: A general trend was seen in which the earlier in the biosynthetic pathway that a mutation occurred, the less able the strain producing the defective sterols could compete with the ergosterol-producing strains. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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