Frank W. Leak
Works (3)
Updated: July 5th, 2023 16:04
1999 journal article
In yeast, upc2-1 confers a decrease in tolerance to LiCl and NaCl, which can be suppressed by the P-type ATPase encoded by ENA2
DNA AND CELL BIOLOGY, 18(2), 133–139.
MeSH headings : Adenosine Triphosphatases / genetics; Cholesterol / pharmacokinetics; Dose-Response Relationship, Drug; Genes, Fungal / genetics; Genetic Complementation Test; Lithium Chloride / pharmacology; Mutation; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins; Sodium Chloride / pharmacology; Sterols / pharmacokinetics; Trans-Activators / genetics
TL;DR:
Wild-type yeast cells are unable to take up sterols from their growth media under aerobic conditions and are relatively resistant to monovalent cations, but a yeast mutant with a defect in the aerobic exclusion of sterols was found to have increased sensitivity to LiCl and NaCl.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae
Journal of Bacteriology, 180(16), 4177–4183.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae
CURRENT GENETICS, 32(2), 93–99.
author keywords: ergosterol; ERG genes; yeast; Saccharomyces
MeSH headings : 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases / genetics; Ergosterol / biosynthesis; Genes, Fungal; Methyltransferases / genetics; Mutation; Oxidoreductases / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / growth & development; Saccharomyces cerevisiae / metabolism; Selection, Genetic
TL;DR:
A general trend was seen in which the earlier in the biosynthetic pathway that a mutation occurred, the less able the strain producing the defective sterols could compete with the ergosterol-producing strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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