Frank W. Leak

Works (3)

Updated: February 10th, 2025 16:10

1999 article

In Yeast, upc2-1 Confers a Decrease in Tolerance to LiCl and NaCl, Which Can Be Suppressed by the P-Type ATPase Encoded by ENA2

Leak, F. W., Tove, S., & Parks, L. W. (1999, February 1). DNA and Cell Biology.

By: F. Leak n, S. Tove* & L. Parks*

MeSH headings : Adenosine Triphosphatases / genetics; Cholesterol / pharmacokinetics; Dose-Response Relationship, Drug; Genes, Fungal / genetics; Genetic Complementation Test; Lithium Chloride / pharmacology; Mutation; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins; Sodium Chloride / pharmacology; Sterols / pharmacokinetics; Trans-Activators / genetics
topics (OpenAlex): Fungal and yeast genetics research; Microbial Metabolic Engineering and Bioproduction; Plant biochemistry and biosynthesis
TL;DR: Wild-type yeast cells are unable to take up sterols from their growth media under aerobic conditions and are relatively resistant to monovalent cations, but a yeast mutant with a defect in the aerobic exclusion of sterols was found to have increased sensitivity to LiCl and NaCl. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae

Journal of Bacteriology, 180(16), 4177–4183.

By: J. Crowley, F. Leak, K. Shianna, S. Tove & L. Parks

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Assessment of the essentiality of ERG genes late in ergosterol biosynthesis in Saccharomyces cerevisiae

Palermo, L. M., Leak, F. W., Tove, S., & Parks, L. W. (1997, September 1). Current Genetics.

By: L. Palermo n, F. Leak n, S. Tove n & L. Parks n

author keywords: ergosterol; ERG genes; yeast; Saccharomyces
MeSH headings : 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases / genetics; Ergosterol / biosynthesis; Genes, Fungal; Methyltransferases / genetics; Mutation; Oxidoreductases / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / growth & development; Saccharomyces cerevisiae / metabolism; Selection, Genetic
topics (OpenAlex): Plant biochemistry and biosynthesis; Fungal and yeast genetics research; Biochemical and biochemical processes
TL;DR: A general trend was seen in which the earlier in the biosynthetic pathway that a mutation occurred, the less able the strain producing the defective sterols could compete with the ergosterol-producing strains. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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