Works (21)
Updated: July 12th, 2023 12:20
2006 journal article
Heparin and fibroblast growth factors affect surfactant protein gene expression in type II cells
American Journal of Respiratory Cell and Molecular Biology, 35(5), 611–618.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and-2 in type II cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(1), L191–L200.
author keywords: extracellular matrix; basement membrane; receptor tyrosine kinase phosphorylation; ERK pathway; fibroblast growth factor signaling
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Heparin / administration & dosage; Heparin / pharmacology; Mitogen-Activated Protein Kinases / metabolism; Phosphorylation / drug effects; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / physiology; Rats; Rats, Inbred Strains; Signal Transduction / drug effects; Sulfates / metabolism; Thymidine / metabolism; Time Factors
TL;DR:
The data suggest that heparin's known capacity to alter DNA synthesis and, possibly, other biological end points is realized via cross talk between multiple signaling pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 article
Modulation of fibroblast growth factor expression and signal transduction in type II cells
Li, C. M., Newman, D., Cesta, M., Tompkins, L., Khosla, J., & Sannes, P. L. (2003, March). CHEST, Vol. 123, pp. 429S–429S.
MeSH headings : Antigenic Modulation / genetics; Antigenic Modulation / immunology; Asthma / genetics; Asthma / immunology; Epithelial Cells / immunology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / immunology; Gene Expression / genetics; Gene Expression / immunology; Humans; In Vitro Techniques; Signal Transduction / genetics; Signal Transduction / immunology
TL;DR:
The data suggests that airway fibroblasts from severe asthmatics may be of a synthetic phenotype, with altered capabilities in collagen production, as compared to those from patients with mild-to-moderate asthma and normal control subjects, and this may be driven by an increased expression of PDGFR.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Effect of growth factor-fibronectin matrix interaction on rat type II cell adhesion and DNA synthesis
EXPERIMENTAL LUNG RESEARCH, 28(2), 69–84.
author keywords: alveolar repair; beta 1integrin; cell-substratum interaction; cytoskeleton; fibroblast growth factors; fibronectin; type II cells
MeSH headings : Actins / metabolism; Animals; Blood Proteins / pharmacology; Cell Adhesion / drug effects; Cell Division / drug effects; Cell Size / drug effects; Cells, Cultured; Cytoskeletal Proteins / metabolism; DNA / biosynthesis; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Fibronectins / pharmacology; Integrin beta1 / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR:
Together FGF-1 and fibronectin appear to promote adhesion, cytoskeletal organization, and in creased DNA synthesis, andin this way influence cell-substratum interactions and signaling during alveolar repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Heparin inhibits DNA synthesis and gene expression in alveolar type II cells
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 27(3), 345–352.
MeSH headings : Animals; Cell Division / drug effects; Cells, Cultured; DNA / biosynthesis; DNA / drug effects; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Heparin / pharmacology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / drug effects; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor / drug effects; Receptors, Fibroblast Growth Factor / genetics; Thymidine / metabolism
TL;DR:
It is demonstrated that sulfated molecules in the ABM may play important regulatory role(s) in selected type II cell activities during normal cell homeostasis, turnover, and repair after lung injury.
(via Semantic Scholar)
open access via citeseerx.ist.psu.edu (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 article
Transforming growth factor-beta(1) modifies fibroblast growth factor-2 production in type II cells
Li, C. M., Khosla, J., Hoyle, P., & Sannes, P. L. (2001, July). CHEST, Vol. 120, pp. 60S–61S.
author keywords: alveolar epithelium; extracellular matrix; growth factors
MeSH headings : Animals; Fibroblast Growth Factor 2 / biosynthesis; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Transforming Growth Factor beta / physiology; Transforming Growth Factor beta1
TL;DR:
Important regulatory links between FGF-2, sulfated ECMs, and both TGF-β 1 and FGF, which could contribute to the modulation of normal cell turnover, development, and repair processes attendant to fibrosis in the lung are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
TGF-beta 1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(6), L1038–L1046.
author keywords: basic fibroblast growth factor; acidic fibroblast growth factor; alveolar epithelium; alveolar injury; pulmonary fibrosis; transforming growth factor
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / metabolism; RNA, Messenger / analysis; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / genetics; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR:
Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factors (TGF)-β1, an important inflammatory cytokine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Development of monoclonal antibodies against bovine mucin core 2 beta 6 N-acetylglucosaminyltransferase
GLYCOCONJUGATE JOURNAL, 16(9), 555–562.
author keywords: core 2 N-acetylglucosaminyltransferase; glycosyltransferase; monoclonal antibodies; mucin
MeSH headings : Animals; Antibodies, Monoclonal / biosynthesis; Blotting, Western; Cattle; Cloning, Molecular; Escherichia coli / genetics; Escherichia coli / metabolism; Fluorescent Antibody Technique; Histidine; Humans; Hybridomas / metabolism; Mice; N-Acetylglucosaminyltransferases / genetics; N-Acetylglucosaminyltransferases / immunology; Peptides / genetics; Recombinant Fusion Proteins / biosynthesis; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / immunology
TL;DR:
Seven hybridomas were obtained which secreted MAbs against bovine C2TF in mouse ascites with titers ranging from 1:1280 to 1:40960 as assessed by immunofluorescence assay (IF), and isotyping revealed that all seven MAbs were IgG (4 IgG1, 2 IgG2b and 1 IgG 2a).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 chapter
Intracellular regulation of airway mucin secretion.
In Cilia, mucus and mucociliary interactions (pp. 143–151).
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Mucin biosynthesis: Molecular cloning and expression of bovine lung mucin core 2 N-acetylglucosaminyltransferase cDNA
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 18(3), 343–352.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Carbohydrate Sequence; Cattle; Cloning, Molecular; DNA, Complementary / genetics; Genomic Library; Immunohistochemistry; Lung / enzymology; Molecular Sequence Data; Mucins / biosynthesis; N-Acetylglucosaminyltransferases / genetics; Recombinant Proteins / biosynthesis; Research Design; Sequence Analysis, DNA; Sequence Homology, Amino Acid
TL;DR:
A cDNA clone containing a 2,150-bp insert was isolated from a bovine lung lambdagt10 cDNA library by cross-species hybridization using a DNA probe generated by polymerase chain reaction (PCR) employing a human cDNA that encodes mucin core 2 beta6-N-acetylglucosaminyltransferase (hC2TF) as the template.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Sulfation of extracellular matrices modifies growth factor effects on type II cells on laminin substrata
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 275(4), L701–L708.
author keywords: sulfated proteoglycans; basement membrane; acidic fibroblast growth factor; basic fibroblast growth factor; keratinocyte growth factor
MeSH headings : Animals; Cell Adhesion / drug effects; Cell Division / drug effects; Cells, Cultured; Chondroitin / pharmacology; Chondroitin Sulfates / pharmacology; Chondroitin Sulfates / physiology; Extracellular Matrix / physiology; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2 / pharmacology; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances / pharmacology; Growth Substances / physiology; Heparin / pharmacology; Heparin / physiology; Heparitin Sulfate / pharmacology; Heparitin Sulfate / physiology; Laminin / pharmacology; Laminin / physiology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344
TL;DR:
It is demonstrated that decreased levels of sulfate in ECM substrata act to upregulate responses to heparin-binding growth factors by alveolar epithelial cells on laminin substrata.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 chapter
Interactions between oxidant gases and airway epithelial cells; in vitro in vivo correlations.
In Correlations between in vitro and in vivo investigations in inhalation toxicology. (pp. 216–229).
Source: NC State University Libraries
Added: August 6, 2018
1997 article
Intracellular regulation of mucin secretion.
Proceedings of the International Congress on Cilia, Mucus and Mucociliary Interations., p. 15.
Source: NC State University Libraries
Added: August 6, 2018
1997 article
Molecular cloning and expression of a mucin core 2 N-acetylglucosaminyltransferase cDNA.
American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A434.
Source: NC State University Libraries
Added: August 6, 2018
1996 article
Nitric oxide: A key signaling molecule regulating airway mucin secretion.
Proceedings of the 9th World Congress on Bronchology & World Congress on Bronchoesophagology., Vol. 9, p. S060.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Oxidant stress stimulates mucin secretion and PLG in airway epithelium via a nitric oxide-dependent mechanism
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 271(5), L854–L861.
author keywords: airway epithelial cells; second messengers; nitric oxide; phospholipase C
MeSH headings : Animals; Cell Transformation, Viral; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium / drug effects; Epithelium / physiology; Guinea Pigs; Humans; Hydrogen Peroxide / pharmacology; Molsidomine / analogs & derivatives; Molsidomine / pharmacology; Mucins / biosynthesis; Mucins / metabolism; Nitric Oxide / pharmacology; Penicillamine / analogs & derivatives; Penicillamine / pharmacology; Peroxides / pharmacology; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxides / pharmacology; Trachea / physiology; Type C Phospholipases / metabolism; Xanthine Oxidase; omega-N-Methylarginine / pharmacology; tert-Butylhydroperoxide
TL;DR:
The results suggest that intracellularly generated radical species of nitrogen and oxygen may be important modulators of the response of airway epithelial cells to external oxidant stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 article
Endogenously-generated nitric oxide (NO) may be a key signaling molecule in hypersecretion of mucin by guinea pig tracheal epithelial (GPTE) cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A337.
Source: NC State University Libraries
Added: August 6, 2018
1995 article
Reactive nitrogen species (RNS) stimulate secretion of mucin by primary cultures of guinea pig tracheal epithelial (GPTE) cells.
American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A337.
Source: NC State University Libraries
Added: August 6, 2018
1994 article
Effects of oxidant stress on airway epithelial cells in vitro.
FASEB Journal, Vol. 8, p. A896.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Interactions of oxygen radicals with airway epithelium.
Environmental Health Perspectives. Supplements, 102(11), 85–90.
MeSH headings : Animals; Antioxidants / metabolism; Epithelium / drug effects; Epithelium / physiopathology; Humans; Oxidoreductases / metabolism; Reactive Oxygen Species / pharmacology; Respiratory System / drug effects; Respiratory System / physiopathology
TL;DR:
Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes and Respiratory epithelium may be intimately involved in defense against, and pathophysiologic changes invoked by, ROS.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST GUINEA-PIG TRACHEAL MUCINS
HYBRIDOMA, 13(4), 281–287.
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Blotting, Western; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Mucins / analysis; Mucins / immunology; Periodic Acid / immunology; Species Specificity; Trachea / chemistry; Trachea / immunology
TL;DR:
Thirty-five hybridomas that secrete mouse monoclonal antibodies against guinea pig tracheal mucins were established and should be useful for immunomeasurement of mucin secretion in vivo and in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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