Works (22)
Updated: July 5th, 2023 16:02
2008 review
Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro
[Review of ]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 40(6-7), 1379–1388.
author keywords: PAR-2; mucin; airway; secretion
MeSH headings : Bronchi / cytology; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Mucins / genetics; Mucins / metabolism; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Oligopeptides / pharmacology; Papillomaviridae / physiology; RNA, Small Interfering / pharmacology; Receptor, PAR-2 / agonists; Receptor, PAR-2 / genetics; Receptor, PAR-2 / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism; Time Factors; Transfection
TL;DR:
The results suggest that, since PAR-2 activation only weakly increases mucin secretion by human airway epithelial cells in vitro,PAR-2 probably is not a significant contributor to mucin hypersecretion in inflamed airways.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 patent
Method and compositions for altering mucus secretion
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
(R)-Albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS
American Journal of Respiratory Cell and Molecular Biology, 34(1), 119–127.
Source: NC State University Libraries
Added: August 6, 2018
2006 patent
Methods for regulating inflammatory mediators and peptides useful therein
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C delta-mediated mechanism
AMERICAN JOURNAL OF PATHOLOGY, 167(3), 651–661.
MeSH headings : Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Cell Differentiation; Cells, Cultured; Enzyme Activation / drug effects; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Isoenzymes / metabolism; Leukocyte Elastase / pharmacology; Mucins / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Protein Kinase C-delta; Protein Kinase Inhibitors / pharmacology
TL;DR:
The results suggest HNE stimulation of mucin release by human airway epithelial cells involves intracellular activation of PKC, specifically the delta isoform.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma
NATURE MEDICINE, 10(2), 193–196.
MeSH headings : Animals; Asthma / metabolism; Bronchi / cytology; Bronchi / metabolism; Bronchi / pathology; Bronchial Provocation Tests; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Disease Models, Animal; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mucins / metabolism; Mucus / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Ovalbumin / administration & dosage; Ovalbumin / immunology; Peptide Fragments / administration & dosage; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Peptides / administration & dosage; Peptides / chemistry; Peptides / pharmacology; Proteins / chemistry; Proteins / genetics; Proteins / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR:
It is shown that the intratracheal instillation of this peptide blocks mucus hypersecretion in a mouse model of asthma, and a pivotal role for MARCKS protein, specifically its N-terminal region, in modulating this secretory process in mammalian airways is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 patent
Blocking peptide for inflammatory cell secretion
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2003 article
A myristoylated peptide directed against the N-terminal region of MARCKS protein inhibits mucin secretion in ovalbumin sensitized/challenged mice in vivo.
American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A17.
Source: NC State University Libraries
Added: August 6, 2018
2003 article
Activation of protease-activated receptors?2 (PAR-2) is not associated with enhanced mucin secretion by well-differentiated normal human bronchial epithelial cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A204.
Source: NC State University Libraries
Added: August 6, 2018
2003 article
Differential effects of albuterol isomers on normal human bronchial epithelial cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A205.
Source: NC State University Libraries
Added: August 6, 2018
2003 article
Human neutrophil elastase provokes release of MUC5B mucin from normal bronchial epithelial cells in vitro via a PKC-dependent mechanism.
American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A203.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Airway epithelium and mucus - Intracellular signaling pathways for gene expression and secretion
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(4), 397–400.
MeSH headings : Animals; Cells, Cultured; Gene Expression Regulation; Humans; Mucin-5B; Mucins / physiology; Mucus / physiology; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Signal Transduction; Uridine Triphosphate / metabolism
TL;DR:
The development of defined, serum-free medium, as well as improvements in the types of substrata beneath the cultured cells, gave researchers the ability to culture airway epithelial cells that looked and acted somewhat like their in vivo counterparts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Enhanced expression of mucin genes in a guinea pig model of allergic asthma
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(5), 644–651.
MeSH headings : Amino Acid Sequence; Animals; Antineoplastic Agents / pharmacology; Asthma / physiopathology; Base Sequence; Bronchial Hyperreactivity / physiopathology; Cells, Cultured; Chemokine CCL11; Chemokines, CC / genetics; Cloning, Molecular; Conserved Sequence; Disease Models, Animal; Eosinophils / immunology; Gene Expression / physiology; Guinea Pigs; Histamine / pharmacology; Hypersensitivity / physiopathology; Inflammation Mediators / pharmacology; Molecular Sequence Data; Mucin 5AC; Mucin-2; Mucins / genetics; Ovalbumin / immunology; Ovalbumin / pharmacology; RNA, Messenger / analysis; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Trachea / cytology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
Results of these studies suggest that the OVA-sensitized guinea pig responds to allergic challenge with enhanced expression of genes that likely play a role in increased airway inflammation and mucin overproduction, and enhanced mucin gene expression appears to occur before eosinophil infiltration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 article
MARCKS protein interaction with the cellular contractile machinery may regulate mucin secretion by human airway epithelium.
American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A225.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro
JOURNAL OF BIOLOGICAL CHEMISTRY, 276(44), 40982–40990.
MeSH headings : Actins / metabolism; Amino Acid Sequence; Cyclic GMP-Dependent Protein Kinases / metabolism; Cytoplasm / metabolism; Down-Regulation; Enzyme Activation; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Exocytosis; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Molecular Sequence Data; Mucins / metabolism; Myosins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C / metabolism; Proteins / physiology; Trachea / cytology; Trachea / enzymology; Trachea / metabolism
TL;DR:
Several novel intracellular targets for pharmacological intervention in disorders involving aberrant secretion of respiratory mucin are suggested and may relate to other lesions involving exocytosis of membrane-bound granules in various cells and tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 article
MARCKS protein: a key intracellular molecule controlling mucin secretion by human airway goblet cells.
American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A259.
Source: NC State University Libraries
Added: August 6, 2018
2000 article
Myristoylated alanine-rich C-kinase substrate protein: A major intracellular regulatory molecule controlling secretion of mucin by human airway goblet cells.
Chest, Vol. 117, pp. 266S–267S.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism
TOXICOLOGY AND APPLIED PHARMACOLOGY, 163(3), 221–230.
author keywords: mucin; cytotoxicity; residual oil fly ash; oxidant
MeSH headings : Animals; Antioxidants / pharmacology; Carbon / toxicity; Cell Survival / drug effects; Cells, Cultured; Coal Ash; Dust / adverse effects; Epithelial Cells / drug effects; Gene Expression / drug effects; Guinea Pigs; Industrial Waste; Metals / toxicity; Mucins / biosynthesis; Mucins / genetics; Mucins / metabolism; Oxidants / pharmacology; Particulate Matter; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Trachea / cytology; Trachea / drug effects; Trachea / metabolism
TL;DR:
ROFA enhances mucin secretion and generates toxicity in vitro to airway epithelium via a mechanism(s) involving generation of oxidant stress, perhaps related to depletion of cellular antioxidant capacity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 article
Myristoylated alanine-rich C kinase substrate (MARCKS) is produced by human airway epithelial cells and is phosphorylated by PKC and PKG.
American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A723.
Source: NC State University Libraries
Added: August 6, 2018
1999 article
Residual oil fly ash (ROFA) increases mucin secretion and mucin gene expression in guinea pig airway epithelial cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A888.
Source: NC State University Libraries
Added: August 6, 2018
1999 article
TNF?-induced ICAM-1 expression in airway epithelium: involvement of IkB?.
American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A184.
Source: NC State University Libraries
Added: August 6, 2018
1998 article
Cloning of guinea pig Muc2 cDNA and MUC2 gene expression in guinea pig airway epithelium in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 157, p. A728.
Source: NC State University Libraries
Added: August 6, 2018
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