@article{tombokan_aguda_danehower_kilpatrick_carbonell_2008, title={Three-component phase behavior of the sclareol-ethyl lactate-carbon dioxide system for GAS applications}, volume={45}, ISSN={["0896-8446"]}, DOI={10.1016/j.supflu.2007.12.007}, abstractNote={This paper focuses on the extraction of sclareol from the leaves of Salvia sclarea Lamiaceae, more commonly known as Clary sage. The process involves the extraction of sclareol using a CO2-soluble GRAS solvent such as ethyl lactate, followed by GAS anti-solvent precipitation from ethyl lactate solution with carbon dioxide. The three-component phase behavior of the sclareol–ethyl lactate–CO2 system at various pressures has been determined and indicates a slight cybotactic effect. The ability of thermodynamic models to predict the complex three-component phase behavior of this system is discussed, together with the implications of the thermodynamic behavior of the system on process design.}, number={2}, journal={JOURNAL OF SUPERCRITICAL FLUIDS}, author={Tombokan, Xenia C. and Aguda, Remil M. and Danehower, David A. and Kilpatrick, Peter K. and Carbonell, Ruben G.}, year={2008}, month={Jun}, pages={146–155} }