@article{martin-jimenez_riviere_2002, title={Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline}, volume={91}, ISSN={["0022-3549"]}, DOI={10.1002/jps.10001}, abstractNote={Differences in the disposition of certain drugs across mammalian species often arise because of their diverse physiology and anatomical characteristics. Factors such as body mass, brain weight, and maximum lifespan are related to the way that different species of mammals handle drugs. Drug disposition data can be scaled across species when chronological time is substituted by the appropriate measure of pharmacokinetic time. In this study, we developed allometric scaling models for oxytetracycline, using serum disposition data obtained from the Food Animal Residue Avoidance Databank. The data were modeled using the mixed-effects modeling approach. The models obtained were validated using disposition data on swine. Oxytetracycline scaled across species based on body weight and the best interspecies model adequately predicted the value of the pharmacokinetic parameters across species. The population approach allows one to estimate the allometric coefficients and exponents of the pharmacokinetic parameters to obtain a model that best fits the multi-species pooled concentration-time data. Furthermore, this approach allows decisions to be made based on the statistical significance of the parameter estimates and the adequacy of the models that are not possible with traditional approaches.}, number={2}, journal={JOURNAL OF PHARMACEUTICAL SCIENCES}, author={Martin-Jimenez, T and Riviere, JE}, year={2002}, month={Feb}, pages={331–341} }
 @article{martin-jimenez_riviere_2001, title={Mixed effects modeling of the disposition of gentamicin across domestic animal species}, volume={24}, ISSN={["0140-7783"]}, DOI={10.1046/j.1365-2885.2001.00346.x}, abstractNote={An interspecies pharmacokinetic model for gentamicin was developed using the mixed effects modeling approach and serum disposition data obtained from the Food Animal Residue Avoidance Databank (FARAD). Data that met a priori quality criteria was obtained from the database and analysed using the traditional double logarithmic analysis and the mixed effects modeling approach. Body weight, brain weight and fever were the covariates of interest in our study. Population pharmacokinetic models across species were developed and validated with swine data. The parameter volume of distribution was modeled as a function of body weight. The total clearance was initially modeled as a function of body weight. The predictability performance of the model improved dramatically when the parameter brain weight was included in the covariate model for clearance. This was a surprising finding worthy of further study. The covariate fever seemed to influence the magnitude of the volume of distribution, although the scarcity of data pertaining to diseased animals makes this finding uncertain. We conclude that the pharmacokinetic characteristics of drugs such as gentamicin, can be predicted across species using a population pharmacokinetics modeling approach, and that clinical features that affect species in a similar manner can be also explored in this fashion.}, number={5}, journal={JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}, author={Martin-Jimenez, T and Riviere, JE}, year={2001}, month={Oct}, pages={321–332} }
 @article{baynes_payne_martin-jimenez_abdullah_anderson_webb_craigmill_riviere_2000, title={Extralabel use of ivermectin and moxidectin in food animals}, volume={217}, ISSN={["0003-1488"]}, DOI={10.2460/javma.2000.217.668}, number={5}, journal={JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Baynes, RE and Payne, M and Martin-Jimenez, T and Abdullah, AR and Anderson, KL and Webb, AI and Craigmill, A and Riviere, JE}, year={2000}, month={Sep}, pages={668–671} }
 @article{martin-jimenez_riviere_2000, title={Mixed effect modelling applied to the interspecies scaling of gentamicin and oxytetracycline}, volume={23}, number={Supp.1 CD}, journal={Journal of Veterinary Pharmacology and Therapeutics}, author={Martin-Jimenez, T. and Riviere, J. E.}, year={2000}, pages={B26} }
 @article{baynes_martin-jimenez_craigmill_riviere_1999, title={Estimating provisional acceptable residues for extralabel drug use in livestock}, volume={29}, ISSN={["1096-0295"]}, DOI={10.1006/rtph.1999.1302}, abstractNote={In 1996, the United States Congress passed legislation (Animal Medicinal Drug Use Clarification Act, AMDUCA), which allows some veterinary or human drugs to be used off label in food-producing animals. In order to implement this Act and protect the U.S. consumer, tolerances or safe concentrations are required before a withdrawal time can be estimated for extralabel drug use. Use of foreign MRLs to satisfy these data needs may not be applicable because of differences in safety standards between the U.S. and other countries. This paper presents strategies that can be used to derive equivalent safe concentrations, referred to as provisional acceptable residues (PARs), that may then be used to estimate drug withdrawal times. Health-based methods are proposed for calculating a PAR for a tissue. Procedure A partitions 50% of the acceptable daily intake (ADI) to edible tissues and reserves the remainder for milk. Procedure B equally partitions the ADI into all edible tissues. Procedure C partitions 50% of the ADI to milk and equally partitions the remaining 50% ADI into edible tissues. Simulations were performed for florfenicol, tetracycline, dexamethasone, azaperone, ivermectin, eprinomectin, and doramectin. In general, these simulations resulted in derivation of conservative PARs, which did not result in daily intakes of residues greater than the health-based ADI. These simulations demonstrated that provided the safe concentrations or equivalent PARs are based on rigorous toxicology safety data (e.g., NOELs, ADIs), the safety of food animal products will not be compromised. It is proposed that these PARs can be used for estimating withdrawal times after extralabel drug use or inadvertent exposure to an environmental contaminant where no approved withdrawal time exists. Finally, implementing similar transparent methods could have a positive impact on international harmonization and trade.}, number={3}, journal={REGULATORY TOXICOLOGY AND PHARMACOLOGY}, author={Baynes, RE and Martin-Jimenez, T and Craigmill, AL and Riviere, JE}, year={1999}, month={Jun}, pages={287–299} }
 @inproceedings{riviere_martin-jimenez_1998, title={Population pharmacokinetics in veterinary medicine. Introduction and overview}, booktitle={Proc. 11th Biennial Symp. Am. Acad. Vet. Pharmacol. Therapeutics}, author={Riviere, J. and Martin-Jimenez, T.}, year={1998}, pages={66–69} }
 @article{martin-jimenez_papich_riviere_1998, title={Population pharmacokinetics of gentamicin in horses}, volume={59}, number={12}, journal={American Journal of Veterinary Research}, author={Martin-Jimenez, T. and Papich, M. G. and Riviere, J. E.}, year={1998}, pages={1589–1598} }
 @article{swanson_wolfe_brown_martinjimenez_riviere_roth_wildt_1997, title={Pharmacokinetics and ovarian-stimulatory effects of equine and human chorionic gonadotropins administered singly and in combination in the domestic cat}, volume={57}, ISSN={["1529-7268"]}, DOI={10.1095/biolreprod57.2.295}, abstractNote={Pregnancy success and embryo survival are low with the use of assisted reproduction in felids treated with exogenous gonadotropins. In this study, the pharmacokinetics and ovarian-stimulatory effects of eCG and hCG were evaluated in the domestic cat. Catheterized anestrual queens (n = 4 per treatment [Trt] group) were given 100 IU eCG i.v. (Trt 1), 100 IU eCG i.m. (Trt 2), 75 IU hCG i.v. (Trt 3), 75 IU hCG i.m. (Trt 4), or 100 IU eCG i.m. followed 80 h later by 75 IU hCG i.m. (Trt 5). Blood samples were collected at 0, 5, 30, and 60 min and 4, 8, 12, 24, 36, 48, 72, 96, 120, 144, and 168 h postinjection, and serum samples were analyzed for estradiol-17beta, progesterone, eCG, and hCG. Pharmacokinetic traits (volume of distribution, Vd; elimination half-life, t1/2beta; clearance rate, Clr) were calculated for eCG and hCG. When i.v. and i.m. administration were compared, no differences (p > 0.05) were observed in follicle or corpus luteum (CL) number or hormone concentrations for queens receiving eCG or hCG alone. Number of mature ovarian follicles (> or = 2 mm diameter) observed at 168 h postinjection did not differ (p > 0.05) for eCG (mean +/- SEM, 10.5 +/- 2.0) vs. hCG (11.1 +/- 3.0), indicating that these were equally effective in inducing follicular growth. In most queens (> 90%) given single gonadotropins (i.m. or i.v.), eCG and hCG persisted in circulation for at least 120 h and 96 h after injection, respectively, reflecting similar (p > 0.05) pharmacokinetic (i.v.) values for Vd (eCG, 91.4 +/- 24.8 ml/kg; hCG, 59.1 +/- 7.9 ml/kg), t1/2beta (eCG, 23.0 +/- 2.4 h; hCG, 22.9 +/- 4.1 h), and Clr (eCG, 2.7 +/- 0.5 ml/h per kg; hCG, 1.8 +/- 0.1 ml/h per kg). Sequential treatment with eCG+hCG did not affect (p > 0.05) the t1/2beta of individual gonadotropins. In summary, eCG and hCG have comparable pharmacokinetics and ovarian-stimulatory activity when administered alone to the domestic cat. These findings suggest that hCG promotes the ancillary follicle formation that is frequently observed after ovulation in cats treated with eCG+hCG regimens, possibly disrupting the maternal environment and decreasing fecundity following assisted reproductive procedures.}, number={2}, journal={BIOLOGY OF REPRODUCTION}, author={Swanson, WF and Wolfe, BA and Brown, JL and MartinJimenez, T and Riviere, JE and Roth, TL and Wildt, DE}, year={1997}, month={Aug}, pages={295–302} }
 @article{martin-jimenez_papich_riviere_1997, title={Population pharmacokinetics of gentamicin in horses}, volume={20}, journal={Journal of Veterinary Pharmacology and Therapeutics}, author={Martin-Jimenez, T. and Papich, M. and Riviere, J.}, year={1997}, pages={27} }
 @inproceedings{martin-jimenez_baynes_craigmill_riviere, title={Extralabel Withdrawal-interval Estimator (EWE) algorithm. An automated approach to establishing extralabel withdrawal times}, volume={11}, booktitle={Proceedings of the 11th Biennial Symposium of American Acadamic Veterinary Pharmacologic Therapeutics}, author={Martin-Jimenez, T. and Baynes, R. and Craigmill, A. and Riviere, J.}, pages={49–63} }