Amy K. Heffelfinger

Works (2)

Updated: July 6th, 2023 21:18

2017 journal article

Disruption of Trim9 function abrogates macrophage motility in vivo

Journal of Leukocyte Biology, 102(6), 1371–1380.

By: D. Tokarz n, A. Heffelfinger n, D. Jima n, J. Gerlach n, R. Shah n, I. Rodriguez-Nunez  n, A. Kortum n, A. Fletcher  n ...

author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains

BMC Evolutionary Biology, 8(1), 177.

By: S. Desai n, A. Heffelfinger n, T. Orcutt n, G. Litman* & J. Yoder n 

MeSH headings : Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / immunology; Genetic Variation; Immunoglobulin Variable Region / genetics; Models, Genetic; Molecular Sequence Data; Multigene Family; Oryzias / genetics; Phylogeny; Protein Structure, Tertiary / genetics; Receptors, Immunologic / genetics; Species Specificity; Synteny; Zebrafish / genetics; Zebrafish / immunology
TL;DR: Comprehensive phylogenetic analyses between the complete datasets of NITRs from medaka and zebrafish indicate multiple species-specific expansions of different families of NITS, consistent with recent birth-and-death events. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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