Daniel J. O'Sullivan

Works (7)

Updated: February 10th, 2025 14:29

1998 article

A leucine repeat motif in AbiA is required for resistance of Lactococcus lactis to phages representing three species.

Dinsmore, P. K., O'Sullivan, D. J., & Klaenhammer, T. R. (1998, May 1). Gene.

By: P. Dinsmore n, D. O'Sullivan n & T. Klaenhammer n

author keywords: lactic acid bacteria; phage resistance; leucine zipper; dairy starter cultures
MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / physiology; Bacteriophages / pathogenicity; Base Sequence; DNA Primers / genetics; Dairy Products / microbiology; Genes, Bacterial; Lactococcus lactis / genetics; Lactococcus lactis / virology; Leucine / genetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Species Specificity; Virulence
topics (OpenAlex): Bacteriophages and microbial interactions; RNA and protein synthesis mechanisms; Genomics and Phylogenetic Studies
TL;DR: Direct mutagenesis analysis of AbiA indicated that the leucine repeat structure is essential for conferring phage resistance against three species of lactococcal bacteriophages. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 patent

Bacteriophage-triggered cell suicide systems and fermentation methods employing the same

Washington, DC: U.S. Patent and Trademark Office.

By: T. Klaenhammer, M. Conkling, D. O'Sullivan, G. Djordjevic, S. Walker & C. Taylor

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Control of expression of LlaI restriction in Lactococcus lactis

O'sullivan, D. J., & Klaenhammer, T. R. (1998, March 1). Molecular Microbiology.

By: D. O'sullivan* & T. Klaenhammer n

MeSH headings : Amino Acid Sequence; Artificial Gene Fusion; Bacterial Proteins; Carrier Proteins / chemistry; Carrier Proteins / genetics; Cloning, Molecular; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Lac Operon; Lactococcus lactis / enzymology; Lactococcus lactis / genetics; Molecular Sequence Data; Mutation; Open Reading Frames; Operon; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Biosynthesis; RNA / isolation & purification; RNA Processing, Post-Transcriptional; Site-Specific DNA-Methyltransferase (Adenine-Specific) / genetics; Transcription, Genetic
topics (OpenAlex): Bacterial Genetics and Biotechnology; Enzyme Structure and Function; Probiotics and Fermented Foods
TL;DR: Investigation of the effect of C·LlaI on enhancement of LlaI restriction in L. lactis revealed that growth at elevated temperatures (40°C) completely abolished any enhancement of restriction activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

A triggered-suicide system designed as a defense against bacteriophages

Djordjevic, G. M., O'Sullivan, D. J., Walker, S. A., Conkling, M. A., & Klaenhammer, T. R. (1997, November 1). Journal of Bacteriology.

By: G. Djordjevic n, D. O'Sullivan n, S. Walker n, M. Conkling n & T. Klaenhammer n

MeSH headings : Amino Acid Sequence; Bacteriophages / genetics; Bacteriophages / growth & development; DNA Restriction-Modification Enzymes / genetics; DNA Restriction-Modification Enzymes / metabolism; Genetic Engineering; Industrial Microbiology / methods; Lactococcus lactis / virology; Molecular Sequence Data; Site-Specific DNA-Methyltransferase (Adenine-Specific) / genetics; Site-Specific DNA-Methyltransferase (Adenine-Specific) / metabolism
topics (OpenAlex): Bacteriophages and microbial interactions; Bacterial Genetics and Biotechnology; RNA and protein synthesis mechanisms
TL;DR: A novel bacteriophage protection system for Lactococcus lactis based on a genetic trap, in which a strictly phage-inducible promoter isolated from the lytic phage phi31 is used to activate a bacterial suicide system after infection, was developed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1996 article

Development of an Expression Strategy Using a Lytic Phage to Trigger Explosive Plasmid Amplification and Gene Expression†

O'Sullivan, D. J., Walker, S. A., West, S. G., & Klaenhammer, T. R. (1996, January 1). Nature Biotechnology.

By: D. O'Sullivan n, S. Walker n, S. West n & T. Klaenhammer n

MeSH headings : Amino Acid Sequence; Bacteriophages / genetics; Base Sequence; Cloning, Molecular; DNA, Viral / genetics; Gene Amplification; Gene Expression Regulation, Viral / physiology; Genome, Viral; Lac Operon; Lactococcus lactis / virology; Molecular Sequence Data; Promoter Regions, Genetic; Transcription, Genetic
topics (OpenAlex): Bacteriophages and microbial interactions; Bacterial Genetics and Biotechnology; Genomics and Phylogenetic Studies
TL;DR: The combination of these phage-inducible expression signals together with ori31 functioned synergistically to drive rapid and high efficiency expression of a heterologous gene in L. lactis. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1995 article

In vivo restriction by LlaI is encoded by three genes, arranged in an operon with llaIM, on the conjugative Lactococcus plasmid pTR2030

O'Sullivan, D. J., Zagula, K., & Klaenhammer, T. R. (1995, January 1). Journal of Bacteriology.

By: D. O'Sullivan n, K. Zagula n & T. Klaenhammer n

MeSH headings : Amino Acid Sequence; Base Sequence; Blotting, Northern; Conjugation, Genetic; Conserved Sequence; DNA Mutational Analysis; DNA Restriction-Modification Enzymes / classification; DNA Restriction-Modification Enzymes / genetics; Frameshift Mutation; Genes, Bacterial / genetics; Lactococcus lactis / genetics; Molecular Sequence Data; Open Reading Frames / genetics; Operon / genetics; Plasmids / genetics; RNA, Bacterial / genetics; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Site-Specific DNA-Methyltransferase (Adenine-Specific) / genetics
topics (OpenAlex): Genomics and Phylogenetic Studies; Bacterial Genetics and Biotechnology; Probiotics and Fermented Foods
TL;DR: The results suggested that the LlaI R/M system is unlike any other R/m system studied to date and has diverged from the type IIS class of restriction enzymes by acquiring some characteristics reminiscent of type I enzymes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1993 article

High- and low-copy-number Lactococcus shuttle cloning vectors with features for clone screening

O'Sullivan, D. J., & Klaenhammer, T. R. (1993, December 1). Gene.

By: D. O'Sullivan n & T. Klaenhammer n

author keywords: ERYTHROMYCIN; LACZ-ALPHA COMPLEMENTATION; LACTIC ACID BACTERIA; STREPTOCOCCUS; THETA REPLICATION
MeSH headings : Cloning, Molecular / methods; Escherichia coli; Genetic Vectors; Lactococcus / genetics; Plasmids; Restriction Mapping
topics (OpenAlex): Glycosylation and Glycoproteins Research; Probiotics and Fermented Foods; Bacterial Genetics and Biotechnology
TL;DR: High- and low-copy-number shuttle cloning vectors were constructed by incorporating the Escherichia coli P15A plasmid origin of replication into the pAM beta 1-derived vectors, pIL252 and pIL253 and displayed good structural stability in Lactococcus and E. coli. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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