@article{pasyukova_roshina_mackay_2004, title={Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan}, volume={3}, ISSN={["1474-9726"]}, DOI={10.1111/j.1474-9728.2004.00114.x}, abstractNote={Summary}, number={5}, journal={AGING CELL}, author={Pasyukova, EG and Roshina, NV and Mackay, TFC}, year={2004}, month={Oct}, pages={297–307} }
 @article{wayne_hackett_dilda_nuzhdin_pasyukova_mackay_2001, title={Quantitative trait locus mapping of fitness-related traits in Drosophila melanogaster}, volume={77}, ISSN={["0016-6723"]}, DOI={10.1017/S0016672300004894}, abstractNote={We examined the genetic architecture of four fitness-related traits (reproductive success, ovariole 
number, body size and early fecundity) in a panel of 98 Oregon-R × 2b3 recombinant inbred lines 
(RILs). Highly significant genetic variation was observed in this population for female, but not 
male, reproductive success. The cross-sex genetic correlation for reproductive success was 0·20, 
which is not significantly different from zero. There was significant genetic variation segregating in 
this cross for ovariole number, but not for body size or early fecundity. The RILs were genotyped 
for cytological insertion sites of roo transposable elements, yielding 76 informative markers with an 
average spacing of 3·2 cM. Quantitative trait loci (QTL) affecting female reproductive success and 
ovariole number were mapped using a composite interval mapping procedure. QTL for female 
reproductive success were located at the tip of the X chromosome between markers at cytological 
locations 1B and 3E; and on the left arm of chromosome 2 in the 30D–38A cytological region. 
Ovariole number QTL mapped to cytological intervals 62D–69D and 98A–98E, both on the third 
chromosome. The regions harbouring QTL for female reproductive success and ovariole number 
were also identified as QTL for longevity in previous studies with these lines.}, number={1}, journal={GENETICAL RESEARCH}, author={Wayne, ML and Hackett, JB and Dilda, CL and Nuzhdin, SV and Pasyukova, EG and MacKay, TFC}, year={2001}, month={Feb}, pages={107–116} }
 @article{vieira_pasyukova_zeng_hackett_lyman_mackay_2000, title={Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster}, volume={154}, number={1}, journal={Genetics}, author={Vieira, C. and Pasyukova, E. G. and Zeng, Z. B. and Hackett, J. B. and Lyman, R. F. and Mackay, T. F. C.}, year={2000}, pages={213–227} }
 @article{gurganus_fry_nuzhdin_pasyukova_lyman_mackay_1998, title={Genotype-environment interaction at quantitative trait loci affecting sensory bristle number in Drosophila melanogaster}, volume={149}, number={4}, journal={Genetics}, author={Gurganus, M. C. and Fry, J. D. and Nuzhdin, S. V. and Pasyukova, E. G. and Lyman, R. F. and MacKay, T. F. C.}, year={1998}, month={Aug}, pages={1883–1898} }
 @article{nuzhdin_keightley_pasyukova_morozova_1998, title={Mapping quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster using changes of marker allele frequencies in divergently selected lines}, volume={72}, ISSN={["1469-5073"]}, DOI={10.1017/S001667239800336X}, abstractNote={Quantitative trait loci (QTLs) responsible for variation in sternopleural
 bristle number in crosses 
between the laboratory lines of Drosophila melanogaster OregonR
 and CantonS were mapped using 
information from allele frequency changes of two families of retrotransposon
 markers in 
divergently selected populations. QTL effects and positions were inferred
 by likelihood, using 
transition matrix iteration and Monte Carlo interval mapping. Individuals
 from the selected 
populations were genotyped for markers spaced at an average distance 4.4
 cM. Four QTLs of 
moderate effect ranging from 0·6 to 1·32 bristles accounted
 for most of the selection response. A 
permutation test of the correspondence between the mapped QTLs and the
 positions of bristle 
number candidate genes suggested that alleles at these candidate genes
 were no more strongly 
associated with selected changes in marker allele frequency than were randomly
 chosen positions in 
the genome.}, number={2}, journal={GENETICS RESEARCH}, author={Nuzhdin, SV and Keightley, PD and Pasyukova, EG and Morozova, EA}, year={1998}, month={Oct}, pages={79–91} }
 @article{fry_nuzhdin_pasyukova_mckay_1998, title={QTL mapping of genotype-environment interaction for fitness in Drosophila melanogaster}, volume={71}, ISSN={["1469-5073"]}, DOI={10.1017/S0016672398003176}, abstractNote={A fundamental assumption of models for the maintenance of genetic
 
variation by environmental 
heterogeneity is that selection favours alternative alleles in different
 
environments. It is not clear, 
however, whether such antagonistic pleiotropy is common. We mapped quantitative
 trait loci 
(QTLs) causing variation for reproductive performance in each of three
 environmental treatments 
among a set of 98 recombinant inbred (RI) lines derived from a cross between
 two D. 
melanogaster laboratory strains. The three treatments were standard
 
medium at 25°C, ethanol-supplemented medium at 25°C, and standard
 
medium at 18°C. The RI lines showed highly 
significant genotype–environment interaction for the fitness measure.
 Of 
six QTLs with significant 
effects on fitness in at least one of the environments, five had 
significantly different effects at the 
different temperatures. In each case, the QTL by temperature interaction
 arose because the QTL 
had stronger effects at one temperature than at the other. No evidence
 for QTLs with opposite 
fitness effects in different environments was found. These results, 
together with those of recent 
studies of crop plants, suggest that antagonistic pleiotropy is a relatively
 uncommon form of 
genotype–environment interaction for fitness, but additional studies
 
of natural populations are needed to confirm this conclusion.}, number={2}, journal={GENETICS RESEARCH}, author={Fry, JD and Nuzhdin, SV and Pasyukova, EG and Mckay, TFC}, year={1998}, month={Apr}, pages={133–141} }
 @article{pasyukova_nuzhdin_filatov_1998, title={The relationship between the rate of transposition and transposable element copy number for copia and Doc retrotransposons of Drosophila melanogaster}, volume={72}, ISSN={["1469-5073"]}, DOI={10.1017/S0016672398003358}, abstractNote={We present data on the relationship between the rate of 
transposition and copy number in the 
genome for the copia and Doc retrotransposons of 
Drosophila melanogaster. copia and Doc 
transposition rates were directly measured in sublines of the 
isogenic 2b line using individual males 
or females, respectively, with a range of copia copy numbers 
from 49 to 103 and Doc copy 
numbers from 112 to 235 per genome. Transposition rates varied from 
3×10−4 to 2×10−2 for 
copia and from 2×10−4 to 2×10−3
 
for Doc. A positive relationship between transposition rate and
 
copy number was found both for copia and for Doc 
when the data were analysed across all the 2b 
individuals; no significant correlation was found when the data 
were analysed across the subline 
means for both retrotransposons tested. Overall, correlation between 
copia and Doc transposition 
rate and their copy number in the genome, if any, was not negative, which
 would be expected if 
transposable elements (TEs) self-regulate their copy number. Thus, 
for copia and Doc no evidence 
for self-regulation was provided, and at least for these two TEs this 
hypothesis is not favoured for 
explaining the maintenance of the stable copy number that is characteristic
 for natural 
populations. The transposition rate of copia was measured 
twice, and a strong positive correlation 
between copy number and transposition rate both across individuals and
 subline means was found 
in 1994, while in 1995 no correlation was found. This fact is in 
agreement with the hypothesis that 
a positive correlation between the rate of transposition and TE copy number
 may be a default 
starting point for future host–TE coevolution.}, number={1}, journal={GENETICS RESEARCH}, author={Pasyukova, EG and Nuzhdin, SV and Filatov, DA}, year={1998}, month={Aug}, pages={1–11} }
 @article{nuzhdin_pasyukova_mackay_1997, title={Accumulation of transposable elements in laboratory lines of Drosophila melanogaster}, volume={100}, ISSN={["1573-6857"]}, DOI={10.1023/A:1018381512384}, number={1-3}, journal={GENETICA}, author={Nuzhdin, SV and Pasyukova, EG and Mackay, TFC}, year={1997}, pages={167–175} }
 @article{pasyukova_nuzhdin_li_flavell_1997, title={Germ line transposition of the copia retrotransposon in Drosophila melanogaster is restricted to males by tissue-specific control of copia RNA levels}, volume={255}, number={1}, journal={Molecular and General Genetics}, author={Pasyukova, E. and Nuzhdin, Sergey V. and Li, W. and Flavell, A. J.}, year={1997}, pages={115–124} }
 @article{nuzhdin_pasyukova_dilda_zeng_mackay_1997, title={Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster}, volume={94}, ISSN={["0027-8424"]}, DOI={10.1073/pnas.94.18.9734}, abstractNote={
            Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural selection late in life allows the accumulation of mutations with deleterious late-age effects that are either neutral (the mutation accumulation hypothesis) or beneficial (the antagonistic pleiotropy hypothesis) early in life. Analyses of
            Drosophila
            spontaneous mutations, patterns of segregating variation and covariation, and lines selected for late-age fertility have implicated both classes of mutation in the evolution of aging, but neither their relative contributions nor the properties of individual loci that cause aging in nature are known. To begin to dissect the multiple genetic causes of quantitative variation in lifespan, we have conducted a genome-wide screen for quantitative trait loci (QTLs) affecting lifespan that segregate among a panel of recombinant inbred lines using a dense molecular marker map. Five autosomal QTLs were mapped by composite interval mapping and by sequential multiple marker analysis. The QTLs had large sex-specific effects on lifespan and age-specific effects on survivorship and mortality and mapped to the same regions as candidate genes with fertility, cellular aging, stress resistance and male-specific effects. Late age-of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of senescence, and sex-specific QTL effects suggest a novel mechanism for maintaining genetic variation for lifespan.
          }, number={18}, journal={PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, author={Nuzhdin, SV and Pasyukova, EG and Dilda, CL and Zeng, ZB and Mackay, TFC}, year={1997}, month={Sep}, pages={9734–9739} }