Works (7)

Updated: August 16th, 2024 13:38

2001 journal article

Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 67(1), 251–259.

By: S. Walker n & T. Klaenhammer n

MeSH headings : Antigens, Bacterial / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacteriophages / enzymology; Bacteriophages / genetics; Bacteriophages / physiology; Culture Media; Genetic Engineering; Lactococcus lactis / enzymology; Lactococcus lactis / genetics; Lactococcus lactis / growth & development; Lactococcus lactis / metabolism; Lysogeny; N-Acetylmuramoyl-L-alanine Amidase; Viral Proteins / genetics; Viral Proteins / metabolism; Virus Integration; beta-Galactosidase / metabolism
TL;DR: A novel system that leaks β-galactosidase (β-gal) without a requirement for secretion or export signals was developed in lactococcus lactis by controlled expression of integrated phage holin and lysin cassettes, pointing toward the development of bacterial strains able to efficiently release relevant proteins and enzymes outside the cell in the absence of known secretion and export signals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

An explosive antisense RNA strategy for inhibition of a lactococcal bacteriophage

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 66(1), 310–319.

By: S. Walker n & T. Klaenhammer n

MeSH headings : Bacteriophages / genetics; Bacteriophages / physiology; Cloning, Molecular; Escherichia coli / genetics; Gene Expression Regulation, Viral; Lactococcus / virology; Open Reading Frames / genetics; Plasmids / genetics; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Antisense / metabolism; RNA, Messenger / metabolism; Replication Origin; Sequence Analysis, DNA; Transformation, Bacterial; Virus Replication
TL;DR: Growth curves performed in the presence of varying levels of phage φ31 showed that ori31plus anti-ORF 4H offered significant protection to Lactococcus lactis, even at multiplicities of infection of 0.01 and 0.1. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 patent

Bacteriophage-triggered cell suicide systems and fermentation methods employing the same

Washington, DC: U.S. Patent and Trademark Office.

By: T. Klaenhammer, M. Conkling, D. O'Sullivan, G. Djordjevic, S. Walker & C. Taylor

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Common elements regulating gene expression in temperate and lytic bacteriophages of Lactococcus species

Applied and Environmental Microbiology, 64(3), 1147–1152.

By: S. Walker, C. Dombroski & T. Klaenhammer

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Molecular characterization of a phage-inducible middle promoter and its transcriptional activator from the lactococcal bacteriophage phi 31

Journal of Bacteriology, 180(4), 921–931.

By: S. Walker & T. Klaenhammer

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

A triggered-suicide system designed as a defense against bacteriophages

JOURNAL OF BACTERIOLOGY, 179(21), 6741–6748.

MeSH headings : Amino Acid Sequence; Bacteriophages / genetics; Bacteriophages / growth & development; DNA Restriction-Modification Enzymes / genetics; DNA Restriction-Modification Enzymes / metabolism; Genetic Engineering; Industrial Microbiology / methods; Lactococcus lactis / virology; Molecular Sequence Data; Site-Specific DNA-Methyltransferase (Adenine-Specific) / genetics; Site-Specific DNA-Methyltransferase (Adenine-Specific) / metabolism
TL;DR: A novel bacteriophage protection system for Lactococcus lactis based on a genetic trap, in which a strictly phage-inducible promoter isolated from the lytic phage phi31 is used to activate a bacterial suicide system after infection, was developed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 patent

Method of making a lactococcal bacteriocin

Washington, DC: U.S. Patent and Trademark Office.

By: P. Vandenbergh, S. Walker & B. Kunkar

Source: NC State University Libraries
Added: August 6, 2018

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