M. P. Carver

Works (11)

Updated: July 5th, 2023 15:53

1991 chapter

Isolated perfused skin flap and skin grafting techniques

In Dermal and ocular toxicology: fundamentals and methods (pp. 297–322). Boca Raton: CRC Press.

By: J. Riviere & M. Carver

Source: NC State University Libraries
Added: August 6, 2018

1990 article

A Physiologically Relevant Pharmacokinetic Model of Xenobiotic Percutaneous Absorption Utilizing the Isolated Perfused Porcine Skin Flap

Williams, P. L., Carver, M. P., & Riviere, J. E. (1990, April 1). Journal of Pharmaceutical Sciences.

By: P. Williams  n, M. Carver n & J. Riviere n

MeSH headings : Animals; Female; In Vitro Techniques; Models, Biological; Perfusion; Skin Absorption; Swine; Xenobiotics / pharmacokinetics
topics (OpenAlex): Pharmacological Effects and Assays; Advancements in Transdermal Drug Delivery; Antibiotics Pharmacokinetics and Efficacy
TL;DR: Model parameters estimated from 8-10-h IPPSF experiments were able to predict 6-day in vivo radiolabel absorptions in pigs for topically applied benzoic acid, caffeine, malathion, parathions, DFP, testosterone, and progesterone, and compare favorably with those obtained previously using a classical compartmental modeling approach. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1990 journal article

Parathion metabolism during percutaneous absorption in perfused porcine skin

Pesticide Biochemistry and Physiology, 38(3), 245–254.

By: M. Carver n, P. Levi n & J. Riviere n

topics (OpenAlex): Pesticide Exposure and Toxicity; Advancements in Transdermal Drug Delivery; Animal testing and alternatives
TL;DR: It is shown that parathion undergoes significant biotransformation following topical application to porcine skin and that the resultant cutaneous metabolite profiles can be altered by both physical (occlusion) and chemical (ABT) means. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

1989 article

Percutaneous absorption and excretion of xenobiotics after topical and intravenous administration to pigs

CARVER, M. (1989, November 1). Fundamental and Applied Toxicology.

By: M. Carver n

MeSH headings : Administration, Topical; Animals; Feces / analysis; Female; In Vitro Techniques; Injections, Intravenous; Skin Absorption; Swine; Xenobiotics / administration & dosage; Xenobiotics / pharmacokinetics
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Contact Dermatitis and Allergies; Dermatology and Skin Diseases
TL;DR: Calculations based on urinary excretion alone underestimated percutaneous absorption determined from total excretion by 5-30%, although the difference between the two estimates was statistically significant only for C (p less than 0.05). (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1989 article

The isolated perfused porcine skin flap

Carver, M. P., Williams, P. L., & Riviere, J. E. (1989, February 1). Toxicology and Applied Pharmacology.

By: M. Carver n, P. Williams  n & J. Riviere n

MeSH headings : Animals; Benzoates / pharmacokinetics; Benzoic Acid; Caffeine / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Models, Biological; Organophosphorus Compounds; Skin Absorption; Steroids / pharmacokinetics; Surgical Flaps; Swine
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Contact Dermatitis and Allergies; Dermatology and Skin Diseases
TL;DR: The results suggest that xenobiotic penetration in the 8-hr IPPSF experiments is highly predictive of in vivo absorption totals (6-day studies), and since pig and human skin are similar physiologically and pharmacologically, theIPPSF may eventually have applications in formulating human dermal risk assessment models. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1986 article

Exaggerated Response to Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats: Identification of a Highly Sensitive Outlier Population

Frazier, D. L., Carver, M. P., Dix, L. P., Thompson, C. A., & Riviere, J. E. (1986, February 1). Toxicologic Pathology.

By: D. Frazier n, M. Carver n, L. Dix n, C. Thompson n & J. Riviere n

MeSH headings : Animals; Blood Urea Nitrogen; Creatinine / blood; Gentamicins / blood; Gentamicins / toxicity; Kidney Diseases / chemically induced; Kidney Tubules / pathology; Kinetics; Male; Necrosis; Rats; Rats, Inbred Strains; Risk
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Drug Transport and Resistance Mechanisms; Drug-Induced Hepatotoxicity and Protection
TL;DR: Post-treatment creatinine and urea nitrogen were not normally distributed in the entire study population, however, when the population was divided into normal and sensitive subgroups, both subgroup values were normally distributed. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

1986 journal article

Identification of a subgroup of Sprague Dawley rats highly sensitive to drug induced renal toxicity

Fundamental and Applied Toxicology, 7, 126–131.

By: J. Riviere, L. Dix, M. Carver & D. Frazier

Source: NC State University Libraries
Added: August 6, 2018

1985 article

Dose-response studies of gentamicin nephrotoxicity in rats with experimental renal dysfunction

Carver, M. P., Shy-Modjeska, J. S., Brown, T. T., Rogers, R. A., & Riviere, J. E. (1985, September 1). Toxicology and Applied Pharmacology.

By: M. Carver n, J. Shy-Modjeska n, T. Brown n, R. Rogers  n & J. Riviere n

MeSH headings : Absorption; Analysis of Variance; Animals; Gentamicins / metabolism; Gentamicins / toxicity; Gentamicins / urine; Glomerular Filtration Rate / drug effects; Injections, Subcutaneous; Kidney / metabolism; Kidney / physiology; Kidney Diseases / chemically induced; Kidney Diseases / pathology; Kinetics; Male; Nephrectomy; Rats; Rats, Inbred Strains
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Drug Transport and Resistance Mechanisms; Metabolism and Genetic Disorders
TL;DR: The relatively lower nephrotoxicity in the FD regimen in rats agrees with results previously reported in dogs, thus indicating that the method of dose reduction in patients with compromised renal function may be a significant factor in lowering neph rotoxic potential. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1985 conference paper

Effects of pre-existing renal disease on aminoglycoside nephrotoxicity in dogs and rats

Renal heterogeneity and target cell toxicity : proceedings of the Second International Symposium on Nephrotoxicity, University of Surrey, UK, 6-9 August 1984, 339–344. Chichester: John Wiley and Sons Ltd.

By: J. Riviere & M. Carver

Source: NC State University Libraries
Added: August 6, 2018

1984 article

Effects of Familial Hypothyroidism and Subtotal Surgical Nephrectomy on Gentamicin Pharmacokinetics in Beagle Dogs

Riviere, E., & Carver, M. P. (1984, January 1). Chemotherapy.

By: E. Riviere n & M. Carver*

MeSH headings : Animals; Dogs; Gentamicins / metabolism; Half-Life; Hypothyroidism / genetics; Hypothyroidism / metabolism; Hypothyroidism / physiopathology; Kinetics; Nephrectomy
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Antibiotics Pharmacokinetics and Efficacy; Coccidia and coccidiosis research
TL;DR: Gentamicin serum pharmacokinetics were studied in normal, subtotally nephrectomized, and familial hypothyroid beagle dogs and length of the gamma phase was not affected by subtotal neph rectomy but was shorter or almost nonexistent in hypothy thyroid dogs. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1984 article

Pharmacokinetics and comparative nephrotoxicity of fixed-dose versus fixed-interval reduction of gentamicin dosage in subtotal nephrectomized dogs

Riviere, J. E., Carver, M. P., Coppoc, G. L., Carlton, W. W., Lantz, G. C., & Shy-Modjeska, J. (1984, September 1). Toxicology and Applied Pharmacology.

By: J. Riviere n, M. Carver n, G. Coppoc*, W. Carlton*, G. Lantz* & J. Shy-Modjeska n

MeSH headings : Analysis of Variance; Animals; Dogs; Female; Gentamicins / administration & dosage; Gentamicins / metabolism; Gentamicins / toxicity; Kidney / drug effects; Kidney / pathology; Kinetics; Metabolic Clearance Rate; Nephrectomy
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Metabolism and Genetic Disorders; Drug Transport and Resistance Mechanisms
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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