Works (11)
Updated: July 5th, 2023 15:53
1991 chapter
Isolated perfused skin flap and skin grafting techniques
In Dermal and ocular toxicology: fundamentals and methods (pp. 297–322). Boca Raton: CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
1990 journal article
A PHYSIOLOGICALLY RELEVANT PHARMACOKINETIC MODEL OF XENOBIOTIC PERCUTANEOUS-ABSORPTION UTILIZING THE ISOLATED PERFUSED PORCINE SKIN FLAP
JOURNAL OF PHARMACEUTICAL SCIENCES, 79(4), 305–311.
MeSH headings : Animals; Female; In Vitro Techniques; Models, Biological; Perfusion; Skin Absorption; Swine; Xenobiotics / pharmacokinetics
TL;DR:
Model parameters estimated from 8-10-h IPPSF experiments were able to predict 6-day in vivo radiolabel absorptions in pigs for topically applied benzoic acid, caffeine, malathion, parathions, DFP, testosterone, and progesterone, and compare favorably with those obtained previously using a classical compartmental modeling approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
Parathion metabolism during percutaneous absorption in perfused porcine skin
Pesticide Biochemistry and Physiology, 38(3), 245–254.
TL;DR:
It is shown that parathion undergoes significant biotransformation following topical application to porcine skin and that the resultant cutaneous metabolite profiles can be altered by both physical (occlusion) and chemical (ABT) means.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1989 journal article
PERCUTANEOUS-ABSORPTION AND EXCRETION OF XENOBIOTICS AFTER TOPICAL AND INTRAVENOUS ADMINISTRATION TO PIGS
FUNDAMENTAL AND APPLIED TOXICOLOGY, 13(4), 714–722.
MeSH headings : Administration, Topical; Animals; Feces / analysis; Female; In Vitro Techniques; Injections, Intravenous; Skin Absorption; Swine; Xenobiotics / administration & dosage; Xenobiotics / pharmacokinetics
TL;DR:
Calculations based on urinary excretion alone underestimated percutaneous absorption determined from total excretion by 5-30%, although the difference between the two estimates was statistically significant only for C (p less than 0.05).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1989 journal article
THE ISOLATED PERFUSED PORCINE SKIN FLAP .3. PERCUTANEOUS-ABSORPTION PHARMACOKINETICS OF ORGANOPHOSPHATES, STEROIDS, BENZOIC-ACID, AND CAFFEINE
TOXICOLOGY AND APPLIED PHARMACOLOGY, 97(2), 324–337.
MeSH headings : Animals; Benzoates / pharmacokinetics; Benzoic Acid; Caffeine / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Models, Biological; Organophosphorus Compounds; Skin Absorption; Steroids / pharmacokinetics; Surgical Flaps; Swine
TL;DR:
The results suggest that xenobiotic penetration in the 8-hr IPPSF experiments is highly predictive of in vivo absorption totals (6-day studies), and since pig and human skin are similar physiologically and pharmacologically, theIPPSF may eventually have applications in formulating human dermal risk assessment models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1986 journal article
Exaggerated response to gentamicin induced nephrotoxicity in Sprague Dawley rats: Identification of a highly sensitive outlier population
Toxicologic Pathology, 14, 204–209.
MeSH headings : Animals; Blood Urea Nitrogen; Creatinine / blood; Gentamicins / blood; Gentamicins / toxicity; Kidney Diseases / chemically induced; Kidney Tubules / pathology; Kinetics; Male; Necrosis; Rats; Rats, Inbred Strains; Risk
TL;DR:
Post-treatment creatinine and urea nitrogen were not normally distributed in the entire study population, however, when the population was divided into normal and sensitive subgroups, both subgroup values were normally distributed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Identification of a subgroup of Sprague Dawley rats highly sensitive to drug induced renal toxicity
Fundamental and Applied Toxicology, 7, 126–131.
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
DOSE-RESPONSE STUDIES OF GENTAMICIN-NEPHROTOXICITY IN RATS WITH EXPERIMENTAL RENAL DYSFUNCTION .1. SUBTOTAL SURGICAL NEPHRECTOMY
TOXICOLOGY AND APPLIED PHARMACOLOGY, 80(2), 251–263.
MeSH headings : Absorption; Analysis of Variance; Animals; Gentamicins / metabolism; Gentamicins / toxicity; Gentamicins / urine; Glomerular Filtration Rate / drug effects; Injections, Subcutaneous; Kidney / metabolism; Kidney / physiology; Kidney Diseases / chemically induced; Kidney Diseases / pathology; Kinetics; Male; Nephrectomy; Rats; Rats, Inbred Strains
TL;DR:
The relatively lower nephrotoxicity in the FD regimen in rats agrees with results previously reported in dogs, thus indicating that the method of dose reduction in patients with compromised renal function may be a significant factor in lowering neph rotoxic potential.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1985 conference paper
Effects of pre-existing renal disease on aminoglycoside nephrotoxicity in dogs and rats
Renal heterogeneity and target cell toxicity : proceedings of the Second International Symposium on Nephrotoxicity, University of Surrey, UK, 6-9 August 1984, 339–344. Chichester: John Wiley and Sons Ltd.
Source: NC State University Libraries
Added: August 6, 2018
1984 journal article
Effects of familial hypothyroidism and subtotal surgical nephrectomy on gentamicin pharmacokinetics in beagle dogs
Chemotherapy, 30, 216–220.
MeSH headings : Animals; Dogs; Gentamicins / metabolism; Half-Life; Hypothyroidism / genetics; Hypothyroidism / metabolism; Hypothyroidism / physiopathology; Kinetics; Nephrectomy
TL;DR:
Gentamicin serum pharmacokinetics were studied in normal, subtotally nephrectomized, and familial hypothyroid beagle dogs and length of the gamma phase was not affected by subtotal neph rectomy but was shorter or almost nonexistent in hypothy thyroid dogs.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1984 journal article
PHARMACOKINETICS AND COMPARATIVE NEPHROTOXICITY OF FIXED-DOSE VERSUS FIXED-INTERVAL REDUCTION OF GENTAMICIN DOSAGE IN SUBTOTAL NEPHRECTOMIZED DOGS
TOXICOLOGY AND APPLIED PHARMACOLOGY, 75(3), 496–509.
MeSH headings : Analysis of Variance; Animals; Dogs; Female; Gentamicins / administration & dosage; Gentamicins / metabolism; Gentamicins / toxicity; Kidney / drug effects; Kidney / pathology; Kinetics; Metabolic Clearance Rate; Nephrectomy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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