Works (20)

Updated: July 28th, 2023 21:16

2011 article

Leflunomide pharmacokinetics after single oral administration to dogs

Singer, L. M., Cohn, L. A., Reinero, C. R., & Papich, M. G. (2011, December). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 34, pp. 609–611.

By: L. Singer*, L. Cohn*, C. Reinero* & M. Papich n

MeSH headings : Administration, Oral; Animals; Chromatography, High Pressure Liquid / veterinary; Crotonates / blood; Crotonates / pharmacokinetics; Dogs / blood; Drug Administration Schedule / veterinary; Female; Half-Life; Hydroxybutyrates; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Isoxazoles / administration & dosage; Isoxazoles / blood; Isoxazoles / pharmacokinetics; Leflunomide; Linear Models; Nitriles; Toluidines / blood; Toluidines / pharmacokinetics
TL;DR: Leflunomide has been used as an adjunctive therapy for dogs refractory to traditional immunosuppressive drugs and to prevent anti-allograft immune responses and all procedures were approved by the NIH Guide for the Care and Use of Laboratory Animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1997 chapter

Airway epithelial cells in asthma.

In Allergy and allergic diseases. (pp. 263–283).

By: L. Cohn, B. Fischer & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1995 article

Endogenously-generated nitric oxide (NO) may be a key signaling molecule in hypersecretion of mucin by guinea pig tracheal epithelial (GPTE) cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A337.

By: B. Fischer, D. Wright, H. Li, C. Li, L. Cohn, N. Akley, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 chapter

Alternatives to in vivo toxicological testing of rodent airway epithelia.

In Animal test alternatives: refinement-reduction-replacement. (pp. 233–239).

By: L. Cohn & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Antioxidant scavenging by guinea pig and human airway epithelial cells in vitro: mechanisms of H2O2 clearance.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 265(10), 397–404.

By: L. Cohn & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1994 article

Effects of oxidant stress on airway epithelial cells in vitro.

FASEB Journal, Vol. 8, p. A896.

By: K. Adler, D. Wright, B. Fischer, L. Cohn, C. Li, H. Li, N. Choe, N. Akley

Source: NC State University Libraries
Added: August 6, 2018

1994 article

INTERACTIONS BETWEEN RESPIRATORY EPITHELIAL-CELLS AND CYTOKINES - RELATIONSHIPS TO LUNG INFLAMMATION

CELLS AND CYTOKINES IN LUNG INFLAMMATION, Vol. 725, pp. 128–145.

By: K. Adler n, B. Fischer n, D. Wright n, L. Cohn n & S. Becker*

MeSH headings : Animals; Asthma / physiopathology; Cytokines / physiology; Epithelial Cells; Epithelium / physiology; Humans; Inflammation / immunology; Inflammation / physiopathology; Lung / cytology; Lung / physiology; Lung / physiopathology; Respiratory Physiological Phenomena; Respiratory System / cytology; Respiratory System / physiopathology
TL;DR: Activity of respiratory epithelial cells in vitro as sources of cytokines and inflammatory mediators is investigated, finding that production and release of these cytokines increases substantially after exposure to specific inflammatory stimuli, such as TNF or IL-1, and after viral infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1994 journal article

Interactions of oxygen radicals with airway epithelium.

Environmental Health Perspectives. Supplements, 102(11), 85–90.

By: D. Wright n, L. Cohn n, H. Li n, B. Fischer n, C. Li n & K. Adler n

MeSH headings : Animals; Antioxidants / metabolism; Epithelium / drug effects; Epithelium / physiopathology; Humans; Oxidoreductases / metabolism; Reactive Oxygen Species / pharmacology; Respiratory System / drug effects; Respiratory System / physiopathology
TL;DR: Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes and Respiratory epithelium may be intimately involved in defense against, and pathophysiologic changes invoked by, ROS. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1993 article

Antioxidant scavenging by guinea pig and human airway epithelial cells in vitro: mechanisms of H2O2 clearance.

American Review of Respiratory Disease, Vol. 147, p. A440.

By: L. Cohn & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1993 chapter

Study of xenobiotics and airway epithelium in vitro.

In Fiber toxicology. (pp. 171–194).

By: L. Cohn, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1993 article

Use of air/liquid interface cultures to assess polarized responses of airway epithelium to toxicants.

In Vitro Cellular & Developmental Biology. Animal, Vol. 29A, p. 46A.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1993 article

Use of air/liquid interface guinea pig tracheal epithelial cell culture systems for assessment of interactions between inhaled substances and airways.

Proceedings of the Toxicology Forum 1993., Vol. 1993.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1992 article

Guinea pig tracheal epithelial cells in primary air/liquid interface culture scavenge H2O2 via a mechanism only partially dependent on catalase and the glutathione system.

FASEB Journal, Vol. 6, p. A939.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

INFLAMMATORY MEDIATORS AND THE GENERATION AND RELEASE OF REACTIVE OXYGEN SPECIES BY AIRWAY EPITHELIUM INVITRO

CHEST, 101(3), S53–S54.

By: K. Adler n, V. Kinnula, N. Akley n, J. Lee n, L. Cohn n & J. Crapo n

MeSH headings : Animals; Cells, Cultured; Endothelins / pharmacology; Epithelium / metabolism; Guinea Pigs; Hydrogen Peroxide / metabolism; Platelet Activating Factor / pharmacology; Trachea / metabolism
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1992 review

INTERACTIONS BETWEEN AIRWAY EPITHELIUM AND MEDIATORS OF INFLAMMATION

[Review of ]. EXPERIMENTAL LUNG RESEARCH, 18(3), 299–322.

By: L. Cohn n & K. Adler n

MeSH headings : Bronchi / metabolism; Epithelial Cells; Epithelium / metabolism; Humans; Inflammation / metabolism; Trachea / metabolism
TL;DR: Recent studies have indicated that airway epithelial cells also can act as "effector" cells, responding to a variety of exogenous and/or endogenous stimuli by generating and releasing additional mediators of inflammation, such as eicosanoids, reactive oxygen species, and cytokines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1991 article

INVITRO STUDIES OF MECHANISMS OF LUNG INJURY IN THE RODENT

TOXICOLOGIC PATHOLOGY, Vol. 19, pp. 419–427.

By: L. Cohn n & K. Adler n

author keywords: RESPIRATORY EPITHELIUM; INVITRO RESPONSE; AIRWAY RESPONSE
MeSH headings : Animals; Cells, Cultured; Epithelium / drug effects; Guinea Pigs; Lung / cytology; Lung / drug effects; Mice; Organ Culture Techniques; Rats; Trachea / drug effects
TL;DR: Several procedures which enhance the differentiated state have been evaluated, which include maintenance on more physiologically-relevant substrata, such as collagen gels, use of defined serum-free medium and use of air/liquid interface systems. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1991 article

In vitro studies on mechanisms of lung injury in the rodent.

Proceedings of the 10th International Symposium of Society of Toxicological Pathologists, Vol. 10.

By: K. Adler & L. Cohn

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Intrahepatic Postsinusoidal Venous Obstruction in a Dog

Journal of Veterinary Internal Medicine, 5(6), 317–321.

By: L. Cohn*, K. Spaulding n, J. Cullen n, S. Bunch, M. Metcalf, E. Hardie, N. MacLachlan n, E. Breitschwerdt*

MeSH headings : Animals; Blood Pressure; Budd-Chiari Syndrome / diagnosis; Budd-Chiari Syndrome / diagnostic imaging; Budd-Chiari Syndrome / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dogs; Female; Hepatic Veins / diagnostic imaging; Hepatic Veins / pathology; Hepatic Veins / physiopathology; Liver / diagnostic imaging; Liver / pathology; Manometry / veterinary; Radiography; Ultrasonography
TL;DR: Intrahepatic postsinusoidal obstruction, similar to congenital Budd-Chiari syndrome in human patients, was diagnosed in a young Basenji dog. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

1991 journal article

THE INFLUENCE OF CORTICOSTEROIDS ON HOST DEFENSE-MECHANISMS

JOURNAL OF VETERINARY INTERNAL MEDICINE, 5(2), 95–104.

By: L. Cohn n

MeSH headings : Adrenal Cortex Hormones / pharmacology; Adrenal Cortex Hormones / physiology; Animals; Antibody Formation / drug effects; Humans; Immunity / drug effects; Immunity, Cellular / drug effects; Leukocytes / drug effects; Phagocytosis / drug effects
TL;DR: This literature review examines the affects of corticosteroids on leukocyte kinetics, phagocytic immunity, cell-mediated immunity, and humoral immunity in steroid-resistant species. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1990 journal article

Bone fragility in a kitten: An osteogenesis imperfecta-like syndrome

Journal of the American Veterinary Medical Association, 197(1), 98.

By: L. Cohn & D. Meuten

Source: NC State University Libraries
Added: August 6, 2018

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