@article{forrest_baty_metcalf_thrall_1996, title={Feline hyperthyroidism: Efficacy of treatment using volumetric analysis for radioiodine dose calculation}, volume={37}, ISSN={["1058-8183"]}, DOI={10.1111/j.1740-8261.1996.tb01212.x}, abstractNote={Hyperthyroidism was diagnosed in 80 cats with thyroid scintigraphy using technetium pertechnetate. These cats were subsequently treated with radioiodine using a modified fixed dose method based on the volume of hyperfunctioning thyroid tissue calculated from the pertechnetate scans. The medical records and thyroid scintigrams were evaluated retrospectively. Follow‐up was obtained on the cats to evaluate treatment success. Several parameters were evaluated in an attempt to identify a difference between treatment success and failure. Cats that failed to become euthyroid after one dose of radioiodine had a significantly higher pretreatment serum thyroxine level, had a significantly larger volume of hyperfunctioning thyroid tissue on scintigrams, and cats receiving oral versus intravenous radioiodine were over represented. Based on our results we conclude: 1) the administration of a dose of radioiodine based solely on the volume of hyperfunctioning thyroid tissue as estimated from the pertechnetate scan may be inadequate for those patients with extremely elevated serum thyroxine levels or large thyroid glands, and 2) oral administration of radioiodine is not recommended for the treatment of feline hyperthyroidism.}, number={2}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={Forrest, LJ and Baty, CJ and Metcalf, MR and Thrall, DE}, year={1996}, pages={141–145} }
 @article{forrest_thrall_1994, title={BONE-SCINTIGRAPHY FOR METASTASIS DETECTION IN CANINE OSTEOSARCOMA}, volume={35}, ISSN={["1740-8261"]}, DOI={10.1111/j.1740-8261.1994.tb00200.x}, abstractNote={The purpose of this study was to assess the usefulness of serial bone scintigraphy in the detection of skeletal and extraskeletal metastases in dogs with appendicular osteosarcoma. Twenty‐six dogs with primary, appendicular osteosarcoma were entered into a limb‐sparing protocol. Bone scintigraphy was performed upon presentation, after neoadjuvant therapy but prior to surgery and at selective intervals after limb‐sparing surgery to evaluate for the presence of metastasis. Thoracic radiographs, and radiographs of other sites, were also made at the time of each bone scan. All dogs had a complete necropsy. No dog had bone or lung metastases detected prior to treatment. The bone scans, medical records, and radiographs of each dog were reviewed retrospectively. All but one dog developed metastatic disease. Bone metastatic sites were confirmed at necropsy in 12 of the 26 dogs. Seven of these 12 dogs had bone metastatic sites which were not producing clinical signs, i.e. an occult metastasis. In five of the seven dogs, the occult site was the first metastatic site detected. Extraskeletal metastases were identified scintigraphically in six of the 26 dogs, but these were clinically apparent prior to bone scintigraphy in each dog. Suspected malignant scintigraphic lesions were proven benign in six dogs. In five dogs with malignant bone lesions at necropsy the last bone scan prior to euthanasia was normal. The time interval between scintigraphy and necropsy was variable in these five dogs. All dogs without bone metastases at necropsy had normal bone scans. This study validates the usefulness of bone scintigraphy for detection of occult bone metastasis and improved ability for tumor staging in dogs with appendicular osteosarcoma.}, number={2}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={FORREST, LJ and THRALL, DE}, year={1994}, pages={124–130} }