@article{godfrey_washburn_eisen_johnson_1994, title={EFFECTS OF CONSUMING ENDOPHYTE-INFECTED TALL FESCUE ON GROWTH, REPRODUCTION AND LACTATION IN MICE SELECTED FOR HIGH FECUNDITY}, volume={41}, ISSN={["0093-691X"]}, DOI={10.1016/0093-691X(94)90191-K}, abstractNote={Effects of a diet containing endophyte-infected tall fescue seed (83% infected) were investigated using 2 lines of mice, one line selected for fecundity (L+) and the other a randomly selected control line (K). Treatments included a commercial stock diet (C), 50% stock plus 50% non-infected tall fescue seed (N), and 50% stock plus 50% infected tall fescue seed (I). The experiment was conducted using mice on respective treatments in 2 phases (successive generations), with 15 to 23 mated females per line and diet subgroups. Mated females of Phase 1 were assigned at random within line to experimental diets which were fed during gestation and through 21 d of lactation. Litters were standardized to 10 pups 1 d after birth. Stock diets were fed to all groups from Day 21 to weaning on Day 28. Weaned male and female pups were allotted to previous diets. Mated females in Phase 2 were managed as in Phase 1 through weaning at 28 d. Diets of males did not affect reproduction and data were pooled within female diets. Selected (L+) dams gave birth to more live pups than K dams (P<0.05) during both phases (+3.4 and +2.8 ± 0.4 pups, respectively). Diet but not line affected littering rate of mated females in Phase 1 (71.3%, I; < 87.1%, C or 93.0%, N; P<0.05) and Phase 2 (82.1%, I < 93.8%, N or 97.1%, C; P<0.05). Diet had no effect on fecundity during Phase 1 but females on I diet had reduced (P<0.05) litter size by 1.9 and 3.2 ± 0.5 pups compared with the females on N and C diets, respectively, in Phase 2. Feed consumption and weights of dams during lactation generally ranked C>N>I. Growth of pups during both phases also ranked C>N>I. Vaginal opening at 28 d differed by line (71.4%, K < 89.3%, L+, P<0.05) and diet (56.8%, I < 92.0%, C or 92.2%, N, P<0.05). These results suggest both acute and chronic effects of consumption of endophyte-infected diets. Absence of line-by-diet interactions demonstrates that adverse effects were unrelated to genetic differences between lines.}, number={7}, journal={THERIOGENOLOGY}, author={GODFREY, VB and WASHBURN, SP and EISEN, EJ and JOHNSON, BH}, year={1994}, month={May}, pages={1393–1409} }