@article{hayaoka_dauterman_1983, title={THE EFFECT OF PHENOBARBITAL INDUCTION ON GLUTATHIONE CONJUGATION OF DIAZINON IN SUSCEPTIBLE AND RESISTANT HOUSE-FLIES}, volume={19}, ISSN={["0048-3575"]}, DOI={10.1016/0048-3575(83)90063-9}, abstractNote={The relationship between glutathione S-transferase activity toward 3,4-dichloronitrobenzene and O-alkyl or O-aryl conjugation of diazinon was investigated in eight strains of house flies. No significant difference was found in the amount of O-aryl conjugation. In contrast, house flies which had higher glutathione S-transferase activity toward 3,4-dichloronitrobenzene also had higher O-alkyl conjugating activity toward diazinon. The glutathione S-transferase(s) in phenobarbital-pretreated flies degraded diazinon faster than those in the nontreated ones. The present results showed that the formation of the O-alkyl conjugate was enhanced by phenobarbital pretreatment, while the formation of the O-aryl conjugate was not affected by induction. Based on these findings, it would appear that one of the multiple forms of glutathione S-transferase is specifically induced and responsible for the increase in O-alkyl conjugation.}, number={3}, journal={PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY}, author={HAYAOKA, T and DAUTERMAN, WC}, year={1983}, pages={344–349} }
 @article{hayaoka_dauterman_1982, title={INDUCTION OF GLUTATHIONE S-TRANSFERASE BY PHENOBARBITAL AND PESTICIDES IN VARIOUS HOUSEFLY STRAINS AND ITS EFFECT ON TOXICITY}, volume={17}, ISSN={["0048-3575"]}, DOI={10.1016/0048-3575(82)90015-3}, abstractNote={The effect of phenobarbital and certain pesticides on glutathione S-transferase activity was investigated. The maximum amount of enzyme induction occurred 96 hr after phenobarbital treatment. Chlorinated hydrocarbons were more effective inducers than the other pesticides evaluated. Phenobarbital treatment did not alter the apparent Km value but altered the Vmax value of glutathione S-transferase to 3,4-dichloronitrobenzene. The amount of reduced glutathione was not increased by phenobarbital treatment. Pretreatment of house flies with phenobarbital provides some protection against methyl parathion, methyl paraoxon, azinphosmethyl, and methidathion toxicity.}, number={2}, journal={PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY}, author={HAYAOKA, T and DAUTERMAN, WC}, year={1982}, pages={113–119} }
 @article{hayaoka_abdelraof_dauterman_1982, title={STUDIES ON THE EFFECT OF PHENOBARBITAL ON GAMMA-GLUTAMYL-TRANSFERASE TRANSFERASE-ACTIVITY IN VARIOUS HOUSEFLY STRAINS}, volume={12}, ISSN={["0020-1790"]}, DOI={10.1016/0020-1790(82)90015-4}, abstractNote={The effect of pretreatment with phenobarbital (PB) on γ-glutamyl transferase (GGT) activity in an insecticide-susceptible housefly strain (CSMA) and three insecticide-resistant housefly strains (Fc, Rutgers, and Hirokawa) was investigated. Pretreatment with PB had little if any effect on GGT activity in the susceptible and resistant housefly strains, indicating that not all the enzymes involved in mercapturic acid biosynthesis in the housefly are inducible.}, number={5}, journal={INSECT BIOCHEMISTRY}, author={HAYAOKA, T and ABDELRAOF, TK and DAUTERMAN, WC}, year={1982}, pages={477–479} }