Susan C. Laws

Works (3)

Updated: July 5th, 2023 15:53

2009 journal article

Chlorotriazine Herbicides and Metabolites Activate an ACTH-dependent Release of Corticosterone in Male Wistar Rats

TOXICOLOGICAL SCIENCES, 112(1), 78–87.

By: S. Laws*, M. Hotchkiss*, J. Ferrell*, S. Jayaraman*, L. Mills*, W. Modic n, N. Tinfo n, M. Fraites*, T. Stoker *, R. Cooper*

author keywords: atrazine; simazine; propazine; adrenal; steroidogenesis; ACTH; corticosterone
MeSH headings : Adrenocorticotropic Hormone / drug effects; Adrenocorticotropic Hormone / physiology; Animals; Corticosterone / metabolism; Dose-Response Relationship, Drug; Herbicides / blood; Herbicides / toxicity; Male; Radioimmunoassay; Rats; Rats, Wistar; Triazines / blood; Triazines / toxicity
TL;DR: The rapid release of ACTH and subsequent activation of adrenal steroidogenesis following a single exposure to ATR, SIM, PRO, DIA, or DEA may reflect chlorotriazine-induced changes at the level of the brain and/or pituitary. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1990 article

ESTRADIOL ALTERS THE EFFECTIVENESS OF GONADOTROPIN-RELEASING HORMONE (GNRH) IN OVINE PITUITARY CULTURES - GNRH RECEPTORS VERSUS RESPONSIVENESS TO GNRH

LAWS, S. C., WEBSTER, J. C., & MILLER, W. L. (1990, July). ENDOCRINOLOGY, Vol. 127, pp. 381–386.

By: S. Laws n, J. Webster n & W. Miller  n

MeSH headings : Animals; Cells, Cultured; Estradiol / pharmacology; Female; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / metabolism; Gonadotropin-Releasing Hormone / pharmacology; Inhibins / pharmacology; Kinetics; Luteinizing Hormone / metabolism; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Receptors, LHRH / metabolism; Sheep
TL;DR: The increase in GnRH receptors caused by E may be important physiologically to help create the preovulatory LH surge; the delayed inhibitory action of E on GnRH-stimulated LH secretion may limit the LH surge. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1990 journal article

INHIBIN INCREASES AND PROGESTERONE DECREASES RECEPTORS FOR GONADOTROPIN-RELEASING HORMONE IN OVINE PITUITARY CULTURE

ENDOCRINOLOGY, 127(1), 373–380.

By: S. Laws n, M. Beggs n, J. Webster n & W. Miller  n

MeSH headings : Animals; Cells, Cultured; Female; Follicle Stimulating Hormone / metabolism; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / metabolism; Gonadotropin-Releasing Hormone / pharmacology; Inhibins / pharmacology; Kinetics; Luteinizing Hormone / metabolism; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Progesterone / pharmacology; Receptors, LHRH / metabolism; Sheep
TL;DR: The data suggest that P may act during the luteal phase to decrease receptors for GnRH during the sheep estrous cycle to permit GnRH receptors to rise under the influence of inhibin (and estradiol) to boost gonadotroph responsiveness to GnRH so the LH surge may occur to its fullest. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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